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  • A non-canonical vitamin K cycle is a potent ferroptosis suppressor

    Authors: Eikan Mishima; Junya Ito; Zijun Wu; Toshitaka Nakamura; Adam Wahida; Sebastian Doll; Wulf Tonnus; Palina Nepachalovich; Elke Eggenhofer; Maceler Aldrovandi; Bernhard Henkelmann; Ken-ichi Yamada; Jonas Wanninger; Omkar Zilka; Emiko Sato; Regina Feederle; Daniela Hass; Adriano Maida; André Santos Dias Mourão; Andreas Linkermann; Edward K. Geissler; Kiyotaka Nakagawa; Takaaki Abe; Maria Fedorova; Bettina Proneth; Derek A. Pratt; Marcus Conrad, 2022

    Published in: Nature

    Tags: Ferroptosis; cell death; vitamin K; naphthoquinones; FSP1-dependent non-canonical; lipid peroxidation

  • Cathodoluminescence imaging of cellular structures labeled with luminescent iridium or rhenium complexes at cryogenic temperatures

    Authors: Marie Vancová; Radim Skoupý; Eva Ďurinová; Tomáš Bílý; Jana Nebesářová; Vladislav Krzyžánek; Aleš Kolouch; Petr Horodyský, 2022

    Published in: Scientfic Reports

    Tags: cathodoluminescence; iridium; rhenium

  • ATP synthase is essential for high conductance but not low conductance Mitochondrial Permeability Transition

    Authors: M.A. Neginskaya; S.E. Morris; E.V. Pavlov, 2022

    Published in: bioRxiv

    Tags: mitochondria; ATP synthase; MTP

  • Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines

    Authors: Maria do Carmo Greier; Annette Runge; Jozsef Dudas; Viktoria Pider; Ira-Ida Skvortsova; Dragana Savic; Herbert Riechelmann, 2022

    Published in: Scientific Reports

    Tags: mitochondria; mesenchymal stem cells; head neck cancer

  • A cold-water polysaccharide-protein complex from Grifola frondosa exhibited antiproliferative activity via mitochondrial apoptotic and Fas/FasL pathways in HepG2 cells

    Authors: Jiahui Zhao; Kaiyue Liang; Hao Zhong; Shizhu Liu; Peilong Sun; Rongjun He, 2022

    Published in: International Journal of Biological Macromolecules

    Tags: G. frondosa; Polysaccharide-protein complex; Cold-water extraction; Structural analysis; HepG2 cell inhibitory activity

  • Laminin Receptor-Mediated Nanoparticle Uptake by Tumor Cells: Interplay of Epigallocatechin Gallate and Magnetic Force at Nano–Bio Interface

    Authors: Sheng-Chieh Hsu; Nian-Ping Wu; Yi-Ching Lu; Yunn-Hwa Ma, 2022

    Published in: Pharmaceutics

    Tags: magnetic nanoparticles; endocytosis; epigallocatechin gallate; 67LR; Akt

  • Comparative analysis of Radachlorin accumulation, localization, and photobleaching in three cell lines by means of holographic and fluorescence microscopy

    Authors: A.A. Zhikhoreva, A.V. Belashov, T.N. Belyaeva, A.V. Salova, I.K. Litvinov, E.S. Kornilova, I.V. Semenova, O.S. Vasyutinskii, 2022

    Published in: Photodiagnosis and Photodynamic Therapy

    Tags: photodynamic treatment, malignant cells, fluorescent analysis, digital holographic microscopy, phase images

  • Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen receptor-positive breast cancer

    Authors: Johanna M. Buschhaus, Shrila Rajendran, Brock A. Humphries, Alyssa C. Cutter, Ayşe J. Muñiz, Nicholas G. Ciavattone, Alexander M. Buschhaus, Tatiana Cañeque, Zeribe C. Nwosu, Debashis Sahoo, Avinash S. Bevoor, Yatrik M. Shah, Costas A. Lyssiotis, Pradipta Ghosh, Max S. Wicha, Raphaël Rodriguez, Gary D. Luker, 2022

    Published in: Oncogene

    Tags: breast cancer, stem cells, iron, lysosome, drug resistance, estrogen-targeted therapy

  • Engineering CpG-ASO-Pt-loaded macrophages (CAP@M) for synergistic chemo-/gene-/immuno-therapy

    Authors: Yuqi Wang, Lingpu Zhang, Yan Liu, Linlin Tang, Juan He, Xiaqing Sun, Muhsin H. Younis, Daxiang Cui, Haihua Xiao, Dong Gao, Xiang-Yang Kong, Weibo Cai, Jie Song, 2022

    Published in: Advanced Healthcare Materials

    Tags: macrophages; antitumor; drug delivery; immunology; immunotherapy; nanomedicine

  • Feature Application: Smart Lipid Droplet Assay LIVE

    In this application note, we showcase some of the potential uses of the Smart Lipid Droplet Assay (SLDA) including quantifying signs of aging in human skin cells (case study 1); investigating LD dynamics during foam macrophage formation (case study 2); examining LD dry mass dynamics in cancer cells (case study 3), and dissecting the details of LD biogenesis (case study 4).