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  • Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus

    Authors: Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel and Martin F. Bachmann

    DOI: https://doi.org/10.3390/vaccines8010116, 2020

    Published in: Vaccines

    Tags: Immunology, type 2 diabetes mellitus, T2DM, diabetes, insulin, amyloid deposits, islet amyloid polypeptide (IAPP), pancreas, pancreatic islets, virus-like particles, VLPs, hyperglycemia, cytokine, IL-1b

  • Stimuli-sensitive fatty acid-based microparticles for the treatment of lung cancer

    Authors: Katarzyna Reczyńska, Patrycja Marchwica, Dipesh Khanal, Tomasz Borowik, Marek Langner, Elżbieta Pamuła, Wojciech Chrzanowski

    DOI: https://doi.org/10.1016/j.msec.2020.110801, 2020

    Published in: Materials and Science Engineering: C

    Tags: Immunooncology & oncology, single cell characterization, drug discovery, lung cancer, cancer therapy, superparamagnetic iron oxide nanoparticles, SPION, solid lipid microparticles, lipid, stimuli-sensitive drug carriers, anticancer drug, paclitaxel, lauric acid, LAU, myrisctic acid, palmitic acid, MYR, PAL, cell viability

  • Neutrophils are mediators of metastatic prostate cancer progression in bone

    Authors: Costanzo-Garvey, D.L., Keeley, T., Case, A.J. et al.

    DOI: https://doi.org/10.1007/s00262-020-02527-6, 2020

    Published in: Cancer Immunology, Immunotherapy

    Tags: Immunooncology & oncology, single cell characterization, neutrophils, bone, metastasis, prostate, cancer, STAT5, prostrate cancer, BM-Pca, immunotherapy, Pca, neutrophils, infiltration, apoptosis, cancer growth, cytotoxicity

  • Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes

    Authors: Svadlakova, T.; Hubatka, F.; Turanek Knotigova, P.; Kulich, P.; Masek, J.; Kotoucek, J.; Macak, J.; Motola, M.; Kalbac, M.; Kolackova, M.; Vankova, R.; Vicherkova, P.; Malkova, A.; Simeckova, P.; Volkov, Y.; Prina-Mello, A.; Kratochvilova, I.; Fiala, Z.; Raska, M.; Krejsek, J.; Turanek, J

    DOI: https://doi.org/10.3390/nano10030418, 2020

    Published in: nanomaterials

    Tags: Immunology, graphene platelets, carbon nanotubes, inflammasome NLRP3, cathepsin B, macrophages, THP-1, bioresistance, proinflammatory, inflammation, canonical pathway, alternative pathway, MWCNT, PAMPs

  • Besnoitia besnoiti bradyzoite stages induce suicidal- and rapid vital-NETosis

    Authors: Ershun Zhou, Liliana M. R. Silva, Iván Conejeros, Zahady D. Velásquez, Manuela Hirz, Ulrich Gärtner, Philippe Jacquiet, Anja Taubert and Carlos Hermosilla

    DOI: https://doi.org/10.1017/S0031182019001707, 2020

    Published in: Parasitology

    Tags: Host-pathogen interactions, microbiology and biofilms, besnoitia besnoiti, apicomplexan parasite, infection, lipid droplets, lipids, apicomplexa, cholesterol synthesis, GC-MS, lovastatin, zaragozic, tachyzoite, cholesterol esterification, parasite, lectin, LDL, autophagy, NETosis, vital NETosis

  • Molecular heterogeneity in breast carcinoma cells with increased invasive capacities

    Authors: Giulia Negro, Bertram Aschenbrenner, Simona Kranjc Brezar, Maja Cemazar, Andrej Coer, Gorana Gasljevic, Dragana Savic, Maxim Sorokin, Anton Buzdin, Maurizio Callari, Irma Kvitsaridze, Anahid Jewett, Mariela Vasileva-Slaveva, Ute Ganswindt, Prof. Ira Skvortsova, Sergej Skvortsov

    DOI: https://doi.org/10.2478/raon-2020-0007, 2020

    Published in: The Journal of Association of Radiology and Oncology

    Tags: Stem cells, Immunooncology & oncology, single cell characterization, breast cancer, metastasis, carcinoma, invasiveness, fibroblast-like, migration, stem cell, tumor growth, hormone receptor-positive, Her2-positive, triple-negative, hormone-positive, cancer stem cells, molecular profiling

  • Enhancement of the biological autoluminescence by mito-liposomal gold nanoparticle nanocarriers

    Authors: Hadi Sardarabadi, Djamel Eddine Chafai, Fatemeh Gheybi, Pezhman Sasanpour, Hashem Rafii-Tabar, Michal Cifra

    DOI: https://doi.org/10.1016/j.jphotobiol.2020.111812, 2020

    Published in: Journal of Photochemistry and Photobiology B: Biology

    Tags: Mitochondria and cell metabolism, drug discovery, immunooncology & oncology, nanocarrier, mitochondria, biological autoluminescence, BAL, ROS, reactive oxygen species, liposome, gold nanoparticle

  • Optimized excystation protocol for ruminant Eimeria bovis- and Eimeria arloingi-sporulated oocysts and first 3D holotomographic microscopy analysis of differing sporozoite egress

    Authors: Sara López-Osorio, Liliana M.R.Silva, Jenny J.Chaparro-Gutierréz, Zahady D.Velazquez, Anja Taubert, Carlos Hermosilla

    DOI: https://doi.org/10.1016/j.parint.2020.102068, 2020

    Published in: Parasitology International

    Tags: Microbiology and biofilms, host-pathogen interactions, eimeria bobis, Eimeria arloingi, excystation, sporulated, sporozoites, cell-parasite, oocysts, method

  • PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

    Authors: Bashar M. Thejer, Partho P. Adhikary, Amandeep Kaur et al.

    DOI: https://doi.org/10.21203/rs.2.22342/v1, 2020

    Published in: BMC Molecular and Cell Biology

    Tags: Immunooncology & oncology, mitochondria and cell metabolism, single cell characterization, mitochondria, migration, invasion, metabolism, cytochrome P450, mesenchymal amoeboid transition, proteomics, tumor biology, progesterone receptor membrane component 1, PGRMC1, cancer, energy metabolism, mitochondrial function

  • Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling

    Authors: Hyunsook Kang, Seong Jun Choi, Kye Hoon Park, Chi-Kyou Lee, and Jong-Seok Moon

    DOI: https://doi.org/DOI: 10.3390/ijms21020476, 2020

    Published in: International Journal of Molecular Sciences

    Tags: Neuroscience, single cell characterization, mitochondria and cell metabolism, glycolysis, EGFR signaling, apoptosis, alcohol, HEI-OC1 cells, glucose metabolism, glucose, auditory sytem, apoptosis, hexokinase 1, HK1, AKT phosphorylation