User Testimonials

“You don’t have to kill them to see how they live.” Federico Faggin, inventor of the microprocessor
Dr. Urs Lüthi

Urs Lüthi

Idorsia Pharmaceuticals Ltd, Switzerland 

“Your data, with its dramatic resolution, provides a prime opportunity to measure the effect that a compound has on the morphology, pattern, and granularity of a cell, which we can use to predict the bioactivity of a compound. If we can identify compound-specific phenotypes, then we can screen other compounds for this phenotypic response and hypothesize that they function via a similar mechanism-of-action.”

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Joanna-Depciuch

Joanna Depciuch

Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland

“When you work with NPs it is essential to characterize: the number of NPs that enter the cells, the site of accumulation and the morphological response of the cells over time. The CX-A is very nice for this as we can quantify how a cell population responds to NPs with different shapes and sizes, while retaining high single-cell resolution”.

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Prof. Oliver Schwartz

Olivier Schwartz

Institut Pasteur, Paris, France

“Our preliminary results captured with the CX-A applied to COVID-19 research are striking and amazing because we have unprecedented details about the cell/cellular organization.”

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Prof. Christophe Dubois

Christophe Dubois

Faculty of Pharmacy, Aix Marseille University, France

“The CX-A allows us to characterize the different effects of drugs on live cells in-vitro, in high resolution and with data that can later be easily analyzed.”

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Michal Cifra

Institute of Photonics and Electronics Academy of Sciences, Czech Republic

“We want to understand how various electromagnetic fields affect the remodeling of the cytoskeleton in real-time with all associated physiological events and Nanolive imaging is an excellent commercial solution for this. We want to use our 3D Cell Explorer-fluo to monitor morphological changes in cells in real time.”

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Patrick Sandoz

KTH Royal Institute of Technology, Stockholm, Sweden

“One of the major advantages of Nanolive imaging is that we can observe contact points between cells, migration patterns and different morphologies, all in an unperturbed system.”

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Gabriel Ichim

Centre for Cancer Research (CRCL) in Lyon, France

“We use our 3D Cell Explorer in all of our on-going projects because it allows us to easily look at the mitochondria without the artifacts of staining or phototoxicity.”

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Joseph T. Rodgers

Assistant Professor, Department of Stem Cell Biology and Regenerative Medicine, The Keck School of Medicine, University of Southern California, USA

“The Nanolive 3D Cell Explorer is a powerful tool to measure morphologic and functional features of live stem cells.”

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 Our laboratory uses primary mouse and human skeletal muscle stem cells (MuSCs), also known as satellite cells, to study the mechanisms that regulate the injury-induced transition of stem cells from quiescent state into the cell cycle. This transition requires many days to complete. MuSCs are a model that allows us to study this transition ex vivo, immediately following FACS-mediated purification from muscle tissue. We have used the Nanolive 3D Explorer to visualize this process in never before seen detail. The accompanying video is of primary MuSCs isolated from a juvenile mouse (5-week-old). The video begins two hours after FACS isolation, each frame is 5 minutes at a frame rate of 18 frames/sec. MuSCs undergo profound changes in size, shape, and function during activation. In the first 24 hours after activation, there is a ~600% increase in cell volume and ~1,000% increase in metabolic activity prior to entering the cell cycle. MuSCs from juvenile mice require 35-40 hours to complete cytokinesis following activation. The kinetics of MuSC activation slow dramatically with age. MuSCs from an adult mouse require twice the amount of time to complete activation as MuSCs from juvenile mice. MuSCs from old mice require 3-4 times longer.

We use the Nanolive 3D Cell Explorer to perform high-resolution analysis of the morphologic and cell biologic features of MuSC activation. These data are producing new insights into the cellular processes involved in activation and mechanisms that underlie age-associated defects in MuSC activation.”

Dr. Shukry J. Habib

Shukry J. Habib, PhD

Principal Investigator, Centre for Stem Cells and Regenerative Medicine King’s College London, London, UK

“This is an excellent technology that allow us to visualise cellular compartments and their rapid dynamics live without the need for staining/ florescence. In combination with advances in segmentation, it will open the door for unprecedented quantitative biology at high temporal resolution.”

Yasmine Abouleila and Ahmed Ali, PhD students

Research Associates, RIKEN Research Institute, Osaka, Japan

“It is amazing to be able to directly visualize the cell in its natural media, without labeling and in 3D. This allowed us to monitor the cell in 3D while sampling part of the cytoplasm and analyzing it using mass spectrometry, thus achieving quantitation on a subcellular space, possibly the first in the world to do so.

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In our lab, we are mainly concerned with understanding biology on a single cell level in a quantitative manner. The 3D Cell Explorer allows us to directly visualize the cell in 3D without labeling and with no sample treatment.Using this technology we were able to be the first in the world to quantitate a biological molecule in subcellular space. By imaging a cell in 3D in less than 1.5 seconds, then taking another 3D image after sampling part of the cell with our proprietary method. By comparing the difference of the 3D image, we could measure the volume sampled in different compartments of the cell such as cytoplasm.”

Oliver Nayler, PhD

Head, Cardiovascular & Fibrosis Biology, Actelion Pharmaceuticals Ltd., Allschwil, Switzerland

“Actelion researchers were among the first to explore the potential of the Nanolive 3D Cell Explorer in cell biological applications within the pharmaceutical industry. We were very happy that the system is so easy to set-up (plug-and-play) and we are still amazed by the beautiful images it generates.

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 We mainly use the Cell Explorer to perform real time image acquisition and we follow compound activity in different cellular backgrounds. In a very short period of time, the 3D Cell Explorer has become very intensively used and we have found applications in several different disease areas – we would not want to be without this instrument.”

Alain Geloen, PhD

CNRS Research Director, member of CarMeN Laboratory, Lyon, France

” […] It is like a window opened on a new world.”  […] “What you did is fantastic. Your microscope is a great achievement. […] You bring a new way to see and to analyze cells. […] You give us the opportunity to read nature with an other physical quantity: the density.

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When I work with your microscope I keep correcting myself, this is not optic [what I see] it is density. In matter of regulations, density is more important than optic. That is why I say we must restudy all the cell biology, not looking at the optic but through the density. I am fully convinced that this is the beginning of a new era in biology. […]

Clemens Grassberger, PhD

Research Fellow, Harvard Medical School & Radiation Oncology, Massachusetts General Hospital, Boston, USA

“The 3D Cell Explorer enables us to study chromatin condensation and nanoparticle uptake in live cancer cells, which wouldn’t be possible with other methods. We are extending this work now to different cancer cell lines to explain variations seen in response to therapy.”

Wojtek Chrzanowski, MSc, PhD, DSc

Senior LecturerFaculty of Pharmacy and the Australian Institute for Nanoscale Science and Technology at the University of Sydney, Australia

“It is absolutely fantastic! Its ease of operation, intuitive nature, compact size, rapid imaging and no need for stains make this a system I would certainly recommend and it would certainly support many different kinds of research.” [learn_more

Read the full story from Dr. Chrzanowski here!

Worldwide Users

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