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  • Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

    Authors: Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl , Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch

    DOI:, 2020 

    Published in: International Journal of Molecular Sciences

    Tags: myeloid cells; primitive macrophages; induced pluripotent stem cells; in vitro characterization; drug discovery; disease modeling

  • Rapid detection of microbiota cell type diversity using machine-learned classification of flow cytometry data

    Authors: Birge D. Özel Duygan, Noushin Hadadi, Ambrin Farizah Babu, Markus Seyfried, Jan R. van der Meer

    DOI:, 2020 

    Published in: Communications Biology

    Tags: Microbiology; methods, machine-learning, aquatic systems, microbiota

  • Apoptosis as the main type of cell death induced by calcium electroporation in rhabdomyosarcoma cells

    Authors: Anna Szewczyk, Jolanta Saczko, Julita Kulbacka

    DOI:, 2020 

    Published in: Bioelectrochemistry

    Tags: rhabdomyosarcoma, muscle cells, calcium ions, electroporation, caspase 3, apoptosis

  • Surface potential and roughness controlled cell adhesion and collagen formation in electrospun PCL fibers for bone regeneration

    Authors: Sara Metwally, Sara Ferraris, Silvia Spriano, Zuzanna J. Krysiak, Łukasz Kaniuk, Mateusz M. Marzec, Sung-Kyun Kim, Piotr K. Szewczyk, Adam Gruszczyński, Magdalena Wytrwal-Sarna, Joanna E. Karbowniczek, Andrzej Bernasik, Sohini Kar-Narayan, Urszula Stachewicz

    DOI:, 2020 

    Published in: Materials & Design

    Tags: surface potential, Kelvin probe force microscopy, zeta potential, cells, adhesion, mineralization, CX-fluo, bone regeneration, interaction, morphology, fibers, osteoblast, MG63

  • Besnoitia besnoiti–driven endothelial host cell cycle alteration

    Authors: Zahady D. Velásquez, Sara Lopez-Osorio, Learta Pervizaj-Oruqaj, Susanne Herold, Carlos Hermosilla, Anja Taubert

    DOI:, 2020

    Published in: Parasitology research

    Tags: Besnoitia besnoiti, apicomplexan parasites, coccidia, cell cycle arrest, CX-fluo, histone H3 S10, cell lysis, lysis, gondii, besnoiti, tachyzoites, PCNA

  • Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause

    Authors: E. Ouni, C. Bouzin, M.M. Dolmans, E. Marbaix, S. Pyr dit Ruys, D. Vertommen, C.A. Amorim

    DOI: https://doi:10.1093/humrep/deaa100, 2020

    Published in: Human Reproduction

    Tags: Ovary, extracellular matrix, hormone replacement therapy, CX, aging, fertility preservation, mechanobiology, elastic matrisome, matrisome, collagen, elastin, EMILIN-1, fiblilin-1, glycosaminoglycan, GAGs, folicle, ECM

  • Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1

    Authors: Kuan-Chou Chen, Chang-Rong Chen, Chang-Yu Chen, Kai-Yi Tzou, Chiung-Chi Peng, Robert Y. Peng

    DOI:, 2020

    Published in: Anticancer Research

    Tags: Oncology and immunooncology, cell metabolism, CX, PC-3 Pca, bicalutamide, Bic, rat mesangial cell, RMC line, mitochondrial dysfunction, HIF-1, oxygen consumption rate, OCR, mitochondria, pgrostate cancer, Pca, cardiovascular damage, renal damage, lactate cehydrogenase, ROS, lysosome, BCL2, caspase-3

  • Netome: The Molecular Characterization of Neutrophil Extracellular Traps (NETs)

    Authors: David Scieszka, Yi-Han Lin, Weizhong Li, Saibyasachi Choudhury, Yanbao Yu, Marcelo Freire

    DOI:, 2020

    Published in: bioRxiv

    Tags: Immunology, single cell characterization, Immunology, single cell characterization, CX, HL60, HL-60, ATCC, NETs, neutrophils, extracellular DNA, genomics, proteomics, NETOME, inflammation, infection, antimicrobial

  • The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells

    Authors: Chien-HanYuan, Yi-LingMa, Po-ChangShih, Chao-TingChen, Shu-YuCheng, Chieh-YuPan, Yen-HsuanJean, Yih-MinChu, Sung-ChunLin, Yu-ChengLai, Hsiao-MeiKuo

    DOI:, 2020

    Published in: Biochemical Pharmacology

    Tags: Immunooncology, oncology, cell metabolism, OS MG63, osteosarcoma, intrinsic apoptosis, TP3, antimicrobial peptide, mitochondria, caspase, blebbing, shrinkage, nuclear fragmentation, chromatin condensation, apoptopodia, ROS, acidification, fission, fusion

  • Feature Application: Characterization of stem cells

    This Feature Application shows the enormous potential of Nanolive technology for observing stem cells in 3D for long periods of time, at unprecedented spatial and temporal resolution (case study 1). We use our technology to capture all the phases of mitosis (case study 2) and the dynamics of stress fiber formation (case study 3), in unparalleled detail. We then showcase our most ground-breaking contribution to this research field, monitoring the sub-cellular morphological changes that occur during stem cell differentiation. We focus on neural differentiation at the single cell (case study 4) and population level (case study 5), before examining the temporal evolution of osteogenic (case study 6) and chrondrogenic differentiation (case study 7) in high resolution.