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  • Preparation of a camptothecin analog FLQY2 self‑micelle solid dispersion with improved solubility and bioavailability

    Authors: Yi Wang; Wenchao Wang; Endian Yu; Wenya Zhuang; Xuanrong Sun; Hong Wang; Qingyong Li

    https://doi.org/10.1186/s12951-022-01596-2, 2022

    Published in: Journal of Nanobiotechnology

    Tags: Camptothecin, Soluplus®, Solid dispersion, Micelle, Solubility, Pharmacokinetics, In vivo antitumor activity

  • Changes of cell membrane fluidity for mesenchymal stem cell spheroids on biomaterial surfaces

    Authors: Chui-Wei Wong; Hao-Wei Han; Shan-hui Hsu

    https://dx.doi.org/10.4252/wjsc.v14.i8.616, 2022

    Published in: World Journal of Stem Cells

    Tags: Cell membrane fluidity; Cell-cell interaction; Cellular spheroids; Chitosan; Hyaluronan

  • Early Pharmacological Profiling of Antiproliferative Compounds by Live Cell Imaging

    Authors: Adrián Puerta; Aday González-Bakker; Guido Santos; José M. Padrón

    https://doi.org/10.3390/molecules27165261, 2022

    Published in: Molecules

    Tags: phenotypic drug discovery; cancer; natural products; live cell imaging; machine learning; antimitotic drugs; microtubule binding drugs

  • Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy

    Authors: Nam Gyu Im; Amy Guillaumet-Adkins; Megha Wal; Anna J. Rogers; Julia Frede; Claire C. Havig; Jing Yang; Praveen Anand; Sarah K. Stegmann; Johannes M. Waldschmidt; Noori Sotudeh; Leili Niu; Jordan Voisine; Michal R. Schweiger; Clemens Grassberger; Jens G. Lohr; Birgit Knoechel

    https://doi.org/10.1158/2326-6066.CIR-21-0626, 2022

    Published in: Cancer Immunology Research

    Tags: CD19; CAR-T; B-cell acute lymphoblastic leukemia; transcriptional plasticity

  • Breast radiotherapy with kilovoltage photons and gold nanoparticles as radiosensitizer: An in vitro study

    Authors: Alessia Tudda; Elisabetta Donzelli; Gabriella Nicolini; Sara Semperboni; Mario Bossi; Guido Cavaletti; Roberta Castriconi; Paola Mangili; Antonella del Vecchio; Antonio Sarno; Giovanni Mettivier; Paolo Russo

    https://doi.org/10.1002/mp.15348, 2021

    Published in: Medical Physics

    Tags: breast cancer, breast radiotherapy, gold nanoparticles, kilovoltage radiotherapy

  • Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer

    Authors: Lu Lu; He Zhang; Yudong Zhou; Jiayi Lin; Weidong Gao; Ting Yang; Jinmei Jin; Lijun Zhang; Dale G. Nagle; Weidong Zhang; Ye Wu; Hongzhuan Chen; Xin Luan

    https://doi.org/10.7150/thno.71129, 2022

    Published in: Theranostics

    Tags: colorectal cancer, stapled mastoparan peptide, peptide-polymer conjugate, immunogenic cell death, oncolytic immunotherapy

  • A murine periodontitis model using coaggregation between human pathogens and a predominant mouse oral commensal bacterium

    Authors: Mengmeng Liu; Youngnim Choi

    https://doi.org/10.5051/jpis.2104360218, 2021

    Published in: Journal of Periodontal & Implant Science

    Tags: Animal models; Mice; Periodontitis; Porphyromonas gingivalis; Streptococcus danieliae

  • Δ9-Tetrahydrocannabinol (Δ9-THC) Improves Ischemia/Reperfusion Heart Dysfunction and Might Serve as a Cardioprotective Agent in the Future Treatment

    Authors: Marta Banaszkiewicz; Paulina Tarwacka; Anna Krzywonos-Zawadzka; Agnieszka Olejnik; Robert Laprairie; Agnieszka Noszczyk-Nowak; Grzegorz Sawicki; Iwona Bil-Lula

    https://doi.org/10.31083/j.fbl2704114, 2022

    Published in: Frontiers in Bioscience-Landmark

    Tags: 5-hydroxytryptamine (5-HT), serotonergic, axon, growth cone, varicosities, development, in vitro, random walk

  • High-Resolution Spatiotemporal Analysis of Single Serotonergic Axons in an In Vitro System

    Authors: Melissa Hingorani; Adele M.L. Viviani; Jenna E. Sanfilippo; Skirmantas Janušonis

    https://doi.org/10.1101/2022.07.16.500161, 2022

    Published in: bioRxiv

    Tags: 5-hydroxytryptamine (5-HT), serotonergic, axon, growth cone, varicosities, development, in vitro, random walk

  • Low-Temperature Synthesis of Hollow β-Tricalcium Phosphate Particles for Bone Tissue Engineering Applications

    Authors: Iman Roohani; Young Jung No; Betty Zuo; Sue D. Xiang; Zufu Lu; Hongwei Liu; Magdalena Plebanski; Hala Zreiqat

    https://doi.org/10.1021/acsbiomaterials.1c01018, 2022

    Published in: ACS Biomaterials Science & Engineering

    Tags: β-tricalcium phosphate, bone tissue engineering, bioceramic, synthesis