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  • Feature Application: Multiparametric cytotoxicity assays

    This Feature Application shows the huge potential that Nanolive imaging holds for the drug discovery process, where cytotoxicity remains one of the major causes of drug withdrawal, and there is an urgent need for reliable and time-saving assay workflows. Our first case study features an in-depth investigation of the dynamics of cell death following exposure to seven cell death stimuli: extreme shifts in external pH, thermal stress, phototoxicity, oxidative stress, Shikonin, Ebastine, and Taxol. Our second case study shows that we can quantify drug-dependent and dose-dependent effects in 96-well plate format.

  • Occurrence of lymphangiogenesis in peripheral nerve autografts contrasts Schwann cell-induced apoptosis of lymphatic endothelial cells in vitro

    Authors: Carina Hromada, Jaana Hartmann, Johannes Oesterreicher, Anton Stoiber, Anna Daerr, Barbara Schädl, Eleni Priglinger, Andreas H. Teuschl-Woller, Wolfgang Holnthoner, Johannes Heinzel, David Hercher

    https://doi.org/10.3390/biom12060820, 2022

    Published in: Biomolecules

    Tags: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells

  • Modulation of mitochondrial electron transport chain by pyroptosis nanoagonists for photoresponsive tumor destruction

    Authors: Penghao Ji, Shenyan Zhang, Peilei Liu, Xi Li, Weichao Bao, Xiangzhi Cui, Minfeng Huo, Jianlin Shi

    https://doi.org/10.1016/j.nantod.2022.101511, 2022

    Published in: Nanotoday

    Tags: Pyroptosis; Oligomycin A; Mitochondrial damage; Oxidative stress; Mild hyperthermia

  • Legumain/pH dual-responsive lytic peptide–paclitaxel conjugate for synergistic cancer therapy

    Authors: Shanshan Zheng, Yue Cai, Yulu Hong, Yubei Gong, Licheng Gao, Qingyong Li, Le Li, Xuanrong Sun

    https://doi.org/10.1080/10717544.2022.2081380, 2022

    Published in: Drug Delivery

    Tags: Peptide–drug conjugate; legumain-responsive; pH-responsive; synergistic cancer therapy

  • Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

    Authors: Shun Li, Florian olde Heuvel, Rida Rehman, Zhenghui Li, Oumayma Aousji, Albrecht Froehlich, Wanhong Zhang, Alison Conquest, Sarah Woelfle, Michael Schoen, Caitlin O´Meara, Richard Lee Reinhardt, David Voehringer, Jan Kassubek, Albert Ludolph, Markus Huber-Lang, Bernd Knöll, Maria Cristina Morganti-Kossmann, Tobias Boeckers, Francesco Roselli 

    https://doi.org/10.1101/2021.12.01.470746, 2021

    Published in: bioRxiv

    Tags: IL-13, synapses, CREB, excitotoxicity, traumatic brain injury

  • ATP purinergic receptor P2X1-dependent suicidal NETosis induced by Cryptosporidium parvum under physioxia conditions

    Authors: Seyed Sajjad Hasheminasab; Iván Conejeros; Zahady D. Velásquez; Tilman Borggrefe; Ulrich Gärtner; Faustin Kamena; Anja Taubert; Carlos Hermosilla 

    https://doi.org/10.3390/biology11030442, 2022

    Published in:Biology

    Tags: Cryptosporidium parvum; NETosis; purinergic receptor P2X1; Notch; glycolysis; PMN

  • N-Acetyl-Cysteine Increases Activity of Peanut-Shaped Gold Nanoparticles Against Biofilms Formed by Clinical Strains of Pseudomonas aeruginosa Isolated from Sputum of Cystic Fibrosis Patients

    Authors: Ewelina Piktel; Urszula Wnorowska; Joanna Depciuch; Dawid Łysik; Mateusz Cieśluk; Krzysztof Fiedoruk; Joanna Mystkowska; Magdalena Parlińska-Wojtan; Paul A Janmey; Robert Bucki

    https://doi.org/10.2147/IDR.S348357, 2022

    Published in: Infection and Drug Resistance

    Tags: gold nanoparticles, non-spherical nanoparticles, N-acetyl-cysteine, bacteria biofilm, cystic fibrosis, Pseudomonas aeruginosa

  • St. Thomas Modified Cardioplegia Effects on Myoblasts’ Viability and Morphology

    Authors: Rafał Nowicki; Katarzyna Biezuska-Kusiak; Julita Kulbacka; Anna Choromanska; Małgorzata Daczewska; Stanisław Potoczek; Maciej Rachwalik; Jolanta Saczko

    https://doi.org/10.3390/medicina58020280, 2022

    Published in: Medicina

    Tags: rat heart myocardium cells; proliferating antigens; thiol groups; cold crystalloid cardioplegia

  • Novel insights into sterol uptake and intracellular cholesterol trafficking during Eimeria bovis macromeront formation

    Authors: Liliana M. R. Silva; Zahady D. Velasquez; Sara Lopez-Osorio; Carlos Hermosilla; Anja Taubert

    https://doi.org/10.3389/fcimb.2022.809606, 2022

    Published in: Frontiers in Cellular and Infection Microbiology

    Tags: LDL sources; cholesterol trafficking; parasite acquisition of nutrients; ezetimibe; progesterone; U18666A

  • Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy

    Authors: Paola Bonaventura; Vincent Alcazer; Virginie Mutez; Laurie Tonon; Juliette Martin; Nicolas Chuvin; Emilie Michel; Rasha E. Boulos; Yann Estornes; Jenny Valladeau-Guilemond; Alain Viari; Qing Wang; Christophe Caux; Stéphane Depil

    https://doi.org/10.1126/sciadv.abj3671, 2022

    Published in: Science Advances

    Tags: adaptive immunity; Human endogenous retroviruses; cancer vaccine; immunotherapy; solid tumors