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  • Feature Application: Characterizing cell metabolism

    This Feature Application highlights the huge potential of Nanolive cell imaging for metabolic studies. We begin by proving that mitochondria and LDs have specific RI signals that allow them to be identified and mapped, in 3D (case study 1). We show that it is possible to image fission-fusion dynamics in mitochondria (case study 2), induce and detect mitochondrial dysfunction (case study 3) and then restore mitochondrial function by the addition of a specific drug (case study 4). Finally, we show that it is possible to quantify LD dynamics in unperturbed (case study 5) and drug-perturbed conditions (case study 6).

  • Feature Application: Characterising cancer cells and their interactions with immune cells

    In this application note, we begin by examining the interactions between t-cells, dendritic cells, and macrophages (case study 1). We then image t-cells responses to cancer cells (case study 2) and the interactions that occur between t-cells and macrophages (case study 3). We show Nanolive imaging can be used to monitor the response of cancer cells to promising antibody drug conjugate (ADCs) products (case study 4) and novel bispecific antibodies (case studies 5 and 6). Finally, we finish with an example of a drug screen where we describe the phenotypic response of living cells to various kinase inhibitors that have shown promise as anti-cancer treatments (case study 7).

  • BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

    Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

    DOI: https://doi.org/10.1117/1.JBO.24.4.046503, 2019

    Published in: Journal of Biomedical Optics

    Tags: Single cell characterization, drug discovery, neuroscience, rat, C6 glial cells, methamphetamine, Raman spectroscopy, apoptosis

  • 3PO as a Selective Inhibitor of 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 in A375 Human Melanoma Cells

    Authors: Kotowski K, Supplitt S, Wiczew D, Przystupski D, Bartosik W, Saczko J, Rossowska J, Drąg-Zalesińska M, Michel O, Kulbacka J.

    DOI: https://doi.org/10.21873/anticanres.14232, 2020

    Published in: Anticancer Research

    Tags: Immunooncology and oncology, B-raf kinase, 3PO, A375, BRAFV600E, Melanoma, PFKFB3, inhibitor, apoptosis, glucose uptake, cycle arrest

  • TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment

    Authors: Ying-Fa Chen, Po-Chang Shih, Hsiao-Mei Kuo, San-Nan Yang, Yen-You Lin, Wu-Fu Chen, Shiow-Jyu Tzou, Hsin-Tzu Liu and Nan-Fu Chen

    DOI: https://doi.org/10.1002/cam4.3005, 2020

    Published in: Cancer Medicine

    Tags: Immunooncology and oncology, neuroscience, cell mobility, glioblastoma multiforme, infiltration, TP3, tumor microenvironment, adhesion, migration, invasion, invasiveness, filopodia, cell attachment, metastasis, kinase, paxillin, RAS, AKT, ERK, JNK, p38

  • Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes

    Authors: Paria Ali Pour, M. Cristina Kenney and Arash Kheradvar

    DOI: https://doi.org/10.1161/JAHA.119.014501, 2020

    Published in: Journal of the American Heart Association

    Tags: Mitochondria and cell metabolism, mitochondrial transplantation, cardiac patients, cardiology, ATP, non-autologous, acute stress

  • Specialized cytonemes induce self-organization of stem cells

    Authors: Sergi Junyent, Clare L. Garcin, James L. A. Szczerkowski, Tung-Jui Trieu, Joshua Reeves, Shukry J. Habib

    DOI: https://doi.org/10.1073/pnas.1920837117, 2020

    Published: National Academy of Sciences

    Tags: Stem cells, development, cell signaling, tissue formation, cell–cell communication, embryogenesis, Wnt

  • Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells

    Authors: Diana Díaz-García, Lucia Sommerova, Andrea Martisova, Hana Skoupilova, Sanjiv Prashar, Tomas Vaculovic, Viktor Kanicky, Isabel del Hierro, Roman Hrstka, Santiago Gómez-Ruiz

    DOI: https://doi.org/10.1016/j.micromeso.2020.110154, 2020

    Published in: Microporous and Mesoporous Materials

    Tags: Drug discovery, immunooncology & oncology, 

  • Advancing methods for the analysis of glioblastoma cell motion using quantitative time lapse holographic imaging and cellular tomography

    Authors: Ed Luther, Livia Mendes, Nina Filiczak, Aditi Jhaveri, Lara Milane, Vladimir Torchilin

    DOI: https://doi.org/10.1117/12.2510236, 2019

    Published in: Society of Photo-Optical Instrumentation Engineers

    Tags: Neuroscience, Immunooncology & Oncology, mitochondria and cell metabolism, glioblastoma, motility, mitochondria, fission, fusion, nanotubes, spheroids

  • Mechanical Properties of cellulose fibers measured by Brillouin spectroscopy

    Authors: Elsayad, K., Urstöger, G., Czibula, C. et al.

    DOI: https://doi.org/10.1007/s10570-020-03075-z, 2020

    Published in: Cellulose 

    Tags: Microbiology and biofilms, 3D cell cultures, storage modulus, Young’s modulus, Loss modulus, Brillouin spectroscopy, Viscoelasticity, Cellulose fiber, viscose fibers, bleached softwood pulp