The 3D Cell Explorer

A label-free live cell imaging microscope to look instantly inside living cells
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Nanolive’s label-free, live cell imaging microscope – the 3D Cell Explorer – is a compact and budget-friendly solution with the ability to observe and measure dynamics of undisturbed living cells

Video: Rotating 3D Cell Explorer

Video: Label-free live cell imaging of a Preadipocyte cell with Nanolive imaging

How Nanolive’s 3D Cell Explorer Can Help You Study Living Cells

  • Explore living cells without damaging them: no Stains, no fixation, no bleaching, no phototoxicity
  • Obtain new insights with label-free 3D characterization of your living cells in physiological conditions without any bleaching or phototoxicity
  • Perform label-free 4D continuous observation of the most sensitive cells from seconds to weeks
  • Preserve the intactness of your cells: Nanolive’s 3D Cell Explorer is the world-leader in live cell assays since it delivers the highest cellular information density anywhere available on the market
  • Rediscover your living cells through multiplexing: Nanolive datasets contain the simultaneous acquisition of several biological features and organelles– therefore capturing various pathways of cell biology in real-time

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The 3D Cell Explorer’s Software

STEVE: An intuitive and comprehensive tool to explore live cell data

Software STEVE UI - Nanolive

Image: Software STEVE UI

STEVE is the 3D Cell Explorer’s software counterpart. After the series of holograms has been captured by the hardware, high-resolution images of each plane in the sample are created by computer processing. Improved image resolution is achieved by employing a synthetic aperture and multiple-viewpoint-holographic methods. 

STEVE’s intuitive interface controls the microscope, explores live cell data using interactive digital staining and even performs quantitative analysis on cell measurements. STEVE runs smoothly, even during acquisition.

Watch the video to learn more about STEVE.

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Applications

Nanolive’s top applications for the 3D Cell Explorer

Neuron on carpet of astrocytes.

High resolution imaging of mitosis in stem cells.

Antibodies being used as a T cell targeting system to wipe out cancer cells.

The 3D Cell Explorer’s Disruptive Technology

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The combination of holography and rotational scanning makes Nanolive imaging a revolutionary technology

Nanolive’s technology is unique because it works label-free and reports the 3D refractive index distribution of the cell. The extremely low light power that generates the holograms allows for a total absence of phototoxicity which leads to excellent time resolution.

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Stem Cells Time Lapse and cell organelles a-f.png

Top Image: 10h time-lapse of mESC undergoing mitosis (Refractive Index and 3D visualization). Bottom image: Organelles which are visible label-free with Nanolive technology: a. mitochondria; b. plasma membrane; c. actin fibers; d. lipid droplets; e. lysosomes; f. nuclear envelope, nucleus & nucleoli.

Laser beam inside 3D Cell Explorer - GIF animation

Schematic of Nanolive’s light path

The 3D Cell Explorer’s Disruptive Technology

Visit our technology page here

The combination of holography and rotational scanning makes Nanolive imaging a revolutionary technology

Nanolive’s technology is unique because it works label-free and reports the 3D refractive index distribution of the cell. The extremely low light power that generates the holograms allows for a total absence of phototoxicity which leads to excellent time resolution.

Request a quote or demo >

Stem Cells Time Lapse and cell organelles a-f.png

Top Image: 10h time-lapse of mESC undergoing mitosis (Refractive Index and 3D visualization). Bottom image: Organelles which are visible label-free with Nanolive technology: a. mitochondria; b. plasma membrane; c. actin fibers; d. lipid droplets; e. lysosomes; f. nuclear envelope, nucleus & nucleoli.

Laser animation gif

Schematic of Nanolive’s light path

Technical Specifications of the 3D Cell Explorer

Nanolive imaging and analysis platforms

Swiss high-precision imaging and analysis platforms that look instantly inside label-free living cells in 3D

3D CELL EXPLORER 96focus

Automated label-free live cell imaging and analysis solution: a unique walk-away solution for long-term live cell imaging of single cells and cell populations

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3D CELL EXPLORER-fluo

Multimodal Complete Solution: combine high quality non-invasive 4D live cell imaging with fluorescence

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3D Cell Explorer front view

3D CELL EXPLORER

Budget-friendly, easy-to-use, compact solution for high quality non-invasive 4D live cell imaging

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