Nanolive Nanolive delivers breakthrough imaging solutions that combine screening, imaging, and analysis to radically advance how scientists study living cells and provide novel biological insights into the mechanisms of cancer and neurodegenerative diseases. Our unique imaging platforms allow scientists to explore living cells in 3D without damaging them. By delivering complete measurements and understandings on a sub-cellular scale (e.g., mitochondrial networks, stem cell differentiation),...

Introduction Dose-response curves provide important pharmacodynamic properties (efficacy, potency, toxicity, and lethality) for evaluating the performance of candidate drugs in the discovery pipeline. Half maximal effective concentration (EC50) values are a standard indicator of drug potency, but recent studies have raised concerns about the robustness and reproducibility of EC50 values generated using current methods, with highly variable values often observed between and within labs. EC50...

In this webinar, Dr. Emma Gibbin-Lameira will show how Nanolive’s label-free, non-invasive imaging can be used to quantify dose-dependent responses of HeLa cells to Chloroquine. Specifically, Dr. Gibbin-Lameira will show that: Dose-dependent experiments can be performed in 96-well plate format over long periods of time (> 2 days), reducing the need for time and labor-intensive multiple fixed-point measurements and eliminating cytotoxic/cytostatic effects arising from the use of labels,...