What is Paclitaxel (Taxol) and how does it work? Paclitaxel, perhaps better known by its brand name Taxol, has long been used as a chemotherapy drug and has been used to treat numerous types of cancer [1]. It is a cytoskeletal drug, which binds to a specific site on β-tubulin [2], a major component of the microtubules that form the structure and shape of eukaryotic cells. Taxol works by stabilizing the microtubule polymer, preventing the disassembly of microtubules during the fourth phase of...

In November 2020 Nanolive attended the Spanish & Portuguese Advanced Optical Microscopy (SPAOM) meeting, held remotely from Valencia in Spain. The objective of this annual congress is to keep new researchers in the Iberian Peninsula at the forefront of optical microscopy and image analysis. There is a strong focus on hands-on workshops and demonstrations at the event, which Nanolive were delighted to be a part of. Seven researchers from across the peninsula agreed to share the data...

In this webinar, Dr. Emma Gibbin-Lameira, Communications Specialist at Nanolive reveals how Nanolive imaging can be used to conduct real-time, automated cytotoxicity assays, without the contribution of photo and cytotoxic methodological artefacts. Specifically, she will: Show high resolution, time-resolved footage of the dynamics of cell death following exposure to six cell death stimuli (extreme shifts in external pH, thermal stress, phototoxicity, oxidative stress, Shikonin and Ebastine)...