A revolutionary non-invasive live cell imaging platform for drug discovery and research

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Nanolive’s technology provides game changing new access to living cells. Our data rich analysis provides new scientific insights that would be missed with simple endpoint or fluorescence-based assays. A revolutionary non-invasive live cell imaging platform for drug discovery and research:

Get higher significance earlier and faster

Reduce your budget costs and simplify your workflow

Miss no detail with our multi-parametric data

Increase experimental relevance

Ensure higher clinical translatability

From cell populations, to organelles

Nanolive imaging is unique in that it allows to image and analyze cells at the population level without compromising the organellular resolution we are renowned for, all for long periods of time (up to weeks), without damage.

Automate to accelerate

  • Unbiased, automated live cell imaging with high content data, increased quality, and minimal artifacts
  • Broaden and deepen decision making to inform R&D investment and de-risk future studies
  • Time and cost savings: no added reagents and lower risk of investing in futile studies

Live cell imaging in the pharmaceutical industry

Live cell imaging is an emerging tool in drug discovery, because it allows to quantify and compare the dynamic responses of unperturbed cells with those of drug-perturbed cells, providing novel mechanistic insights into the responses of cells to candidate drugs. With Nanolive technology, data is richer and more reliable because information is collected from multiple sub-cellular compartments simultaneously (multiplexing) in a totally non-invasive fashion, meaning results are not compromised by methodological artefacts such as phototoxicity and/or photobleaching.

An automated solution to accelerate your workflow

Nanolive’s automated solution for Drug Discovery and Research, the CX-A, can perform multiple drug perturbation assays in parallel, live and over long periods of time, in a fully automated manner accelerating your workflow.

Using Nanolive’s solution, researchers get higher significance, earlier and faster.

CX-A with 96-WP from Nanolive

Reduce workflow complexity to save time and money

Biotech and Pharma workflow

LIVE T Cell Assay

Label-free AI-assisted segmentation of target cells and T cells in co-culture

The LIVE T Cell Assay offers a unique opportunity to understand T cell/target cells interactions over time, at both the single-cell and population level. Nanolive’s label-free live cell imaging captures detailed, multiplexed, and texturally rich images of the entire T cell response process: find, bind, stress and kill.

Only Nanolive’s rich images can achieve a clear segmentation of T cells and their targets without using any destructive labels.

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Investigate cytotoxicity, mechanisms of cell death, and calculate kinetic EC50 values

Unbiased, non-invasive, and continuous quantification of multiple metrics provides invaluable information about the cytotoxicity of drugs and mechanisms of cell death.

  • Quantify dynamic responses to cytotoxicity and cell death events
  • Identify and characterize sub-cellular processes and cell interactions at the population level simultaneously
  • Access novel metrics such as dry mass and granularity that are impossible using fluo-based techniques
  • When combined with dose response experiments, our high content data can be used to calculate kinetic EC50 values; an excellent indicator of drug stability.

Video: Cell death in glioblastoma and pre-adipocyte cells following exposure to a Receptor Tyrosine Kinase (RTK) inhibitor

Video: Calculate kinetic EC50 values to investigate drug stability and performance over time

Analyze precious sensitive samples

First and only technology to continuously identify and characterize differentiation of highly delicate stem cells.

  • Image stem cells at unprecedented spatial and temporal resolution without the addition of genetic or fluorescence labels
  • Monitor dynamic alterations in cell morphology, metabolic activity and responsiveness as stem cells undergo differentiation
  • Identify cells based on shape and refractive index (RI) texture

Video:Capturing the deposition and early growth of bone that occur during osteogenic differentiation

Video: Stem cell differentiating into neuronal cells

Capture and characterize interactions with target cells

The first and only solution to monitor and characterize the dynamics of T-cells and their targets.

  • Profile immuno-oncology and cell therapy products such as CAR-T cells, monoclonal antibodies, or bispecifics
  • Monitor dynamic interactions between immune cells and cancer cells at unparalleled, sub-cellular detail, in 3D
  • Visualize changes in cell morphology and behavior as immune and cancer cells interact

Video: Antibodies being used as a T-cell targeting system to wipe out cancer cells

Video: T-cells killing macrophages and macrophages eating macrophage

Webinar: “Increase biological relevance and simplify your discovery workflow”

Maximize the biological relevance of your data whilst shortening and simplifying your experimental workflow: EVE Analytics & the CX-A webinar photo

In this webinar, Dr. Emma Gibbin-Lameira, Communications Specialist at Nanolive:

  • A step-by-step guide to setting-up an experiment and acquiring images with Nanolive’s automated microscope the CX-A, and creating publication-ready data and images using Nanolive’s new quantification solution, EVE Analytics
  • A case study showing how different stress stimuli (cytotoxicity vs. phototoxicity) invoke different types of cell death
  • An in-depth discussion of how cell metrics can be used to quantify different types of cell death

Please register here to view the webinar on-demand