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  • A Gain-Of-Function RAC2 Mutation Is Associated With Bone-Marrow Hypoplasia And An Autosomal Dominant Form Of Severe Combined Immunodeficiency

    Authors: Chantal Lagresle-Peyrou, Aurélien Olichon, Hanem Sadek, Philippe Roche, Claudine Tardy, Cindy Da Silva, Alexandrine Garrigue, Alain Fischer, Despina Moshous, Yves Collette, Capucine Picard, Jean Laurent Casanova, Isabelle André, Marina Cavazzana

    DOI: https://doi.org/10.3324/haematol.2019.230250, 2020

    Published in: Haematologica

    Tags: Immunology, severe combined immunodeficiencies, SCIDs, T cells, B cells, leukopenia, RAC2 gene, p.G12R, hematopoietic stem cell transplantation, stem cell, gain of function

  • A potential hydrodynamic mechanism for cytoplasmic transfer between mammalian cells: Cell-projection pumping

    Authors: Hans Zoellner, Navid Paknejad, James Cornwell, Belal Chami, Yevgeniy Romin, Vitaly Boyko, Sho Fujisawa, Elizabeth Kelly, Garry W. Lynch, Glynn Rogers, Katia Manova, Malcolm A.S. Moore

    DOI: https://doi.org/10.1101/531798, 2020

    Published in: BioRxiv

    Tags: Single cell characterization, human fibroblasts, malignant cells, tunneling nanotubes, TNT, shed membrane vesicles, cell-projection pumping, CPP

  • Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux

    Authors: Patrick A. Sandoz, Christopher Tremblay, F. Gisou van der Goot, Mathieu Frechin 

    DOI: https://doi.org/10.1371/journal.pbio.3000553, 2019

    Published in: PLOS Biology

    Tags: Single cell characterization, stem cells, lipid droplets, mitochondria, endocytosis, endocytic structures, cell division, spinning, nuclear rotation

  • E-Cigarette Use Increases Susceptibility to Bacterial Infection by Impairment of Human Neutrophil Chemotaxis, Phagocytosis and NET Formation

    Authors: Ross Corriden, Alexander Moshensky, Christine M Bojanowski, Angela Meier, Jason Chien, Ryan K Nelson, Laura E. Crotty Alexander

    DOI: https://doi.org/10.1152/ajpcell.00045.2019, 2019

    Published in: American Journal of Physiology

    Tags: Immunology, single cell characterization, chemotaxis, E-cigarette, human neutrophils, neutrophil extracellular trap, Pseudomonas; reactive oxygen species, sepsis

     

  • S-Nitrosothiol Plasma-Modified Surfaces for the Prevention of Bacterial Biofilm Formation

    Authors: Zahra Sadrearhami, Rashin Namivandi-Zangeneh, Emily Price, Marta Krasowska, Sameer A Al-Bataineh, Jason Whittle, Edgar H. H. Wong, Anton Blencowe, Cyrille Boyer

    DOI: https://doi.org/10.1021/acsbiomaterials.9b01063, 2019

    Published in: ACS Biomater. Sci. Eng

    Tags: Microbiology and biofilms, host-pathogen interactions, plasma polymerization, antibacterial coating, biofilm, S-nitrosothiol, surface modification, bacterial infection, infection, nosocomial, gram-negative, Pseudomonas aeruginosa

  • Toxoplasma gondii-induced host cellular cell cycle dysregulation is linked to chromosome missegregation and cytokinesis failure in primary endothelial host cells

    Authors: Velásquez ZD, Conejeros , Larrazabal C , Kerner K, Hermosilla C, Taubert A.

    DOI: https://doi.org/10.1038/s41598-019-48961-0, 2019

    Published in: Scientific Reports

    Tags: Host-pathogen interaction, single cell characterization, Microbiology and biofilms, toxoplasma gondii, zoonotic, intracellular, parasite, lysis, cell cylce, cell division, entothelial cells, multi-nucleation, cyclin B1, chromosome, mitotic spindle, cytokinesis, Aurora B, chromosome segregation, cytokinesis

  • Beyond the suprachiasmatic nucleus: circadian rhythmicity shapes astrocyte morphology and neuronal function in hippocampal area CA1

    Authors: John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander Khmaladze, Alexey Semyanov, Michele Migliore and Annalisa Scimemi

    DOI: https://doi.org/10.1101/666073, 2019

    Published in: bioRxiv

    Tags: Neuroscience, single cell characterization, suprachiasmatic nucleus, SCN, hypothalamus, rhythmic activity, memory-dependent, hippocampus, CA1, circadian rhythmicity, synaptic transmission, pyramidal neurons, NMDA receptors, astrocytes

  • Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

    Authors: Wen-Yueh Hung, Jer-Hwa Chang, Yu Cheng, Guo-Zhou Cheng, Hsiang-Ching Huang, Michael Hsiao, Chi-Li Chung, Wei-Jiunn Lee and Ming-Hsien Chien

    DOI: https://doi.org/10.1038/s41419-019-1785-9, 2019

    Published in: Cell Death & Disease

    Tags: Drug discovery, immunooncology & oncology, mitochondria and cell metabolism, anticancer, chemotherapy, apoptosis, autophagy, drug discovery, penfluridol, lung cancer, antitumor, non-small-cell lung cancer, NSCLC, orthotopic xenograft model, viability, motility, p38

  • Quantification of changes in cellular morphology during cell necrosis obtained from 3D refractive index distributions

    Authors: D A Gorbenko, A V Belashov, T N Belyaeva, E S Kornilova, I V Semenova and O S Vasyutinskii

    DOI: https://doi.org/10.1088/1742-6596/1236/1/012015, 2019

    Published in: Journal of Physics

    Tags: Single cell characterization, photodynamic treatment, cellular morphology, apoptosis, necrosis, cell membrane

  • Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

    Authors: T. B. Steinbichler, D. Savic, D. Dejaco, A. Romani, B. Kofler, I. I. Skvortsova, H. Riechelmann, J. Dudas

    DOI: https://doi.org/10.1007/s12307-019-00228-y, 2019

    Published in: Cancer Microenvironment

    Tags: Drug discovery, immunooncology & oncology, mitochondria and cell metabolism, epithelial mesenchymal crosstalk, EMC, tumor, tumor stroma, associated fibroblasts, cancer, head and neck cancer, chemotherapy, IL-6, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium