Nano News
Looking inside Nanolive
Perturbation of living cells with kinase inhibitors
Background In this case study, we expose cells to inhibitors or modulators of kinase activity and observe how the cells respond. Hyperactivity, malfunction or overexpression of kinases is the root cause of many human cancers, and so the development of kinase...
6 new scientific publications using Nanolive cell imaging
We are delighted to announce SIX exciting new articles featuring Nanolive’s 3D Cell Explorer. The articles come from users based in Taiwan, Poland, Spain, and Belgium, respectively. TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma...
3 new parasitology publications from Justus Liebig University (Giessen, Germany)
We are delighted to announce three very exciting new PARISITOLOGY articles featuring Nanolive’s 3D Cell Explorer – ALL of which have been published this year by our prolific clients at the Justus Liebig University (Giessen, Germany) and their co-authors in Colombia...
Join Nanolive’s webinar “Accelerating oncology drug discovery with label-free imaging” on July 7th
We are happy to announce our next webinar with the topic "Accelerating oncology drug discovery with label-free imaging" on July 7th and 8th. In this webinar, Dr. Emma Gibbin, Communications Specialist at Nanolive will discuss the advantages of using label-free live...
A stem cell differentiation story
Mesenchymal stem cells (MSCs) hold great promise for regenerative medicines such as cell therapy and tissue engineering (1,2). These approaches require cells to be grown in culture and differentiated into specific cell types such as osteoblasts (bone cells),...
High resolution live footage of the formation and spontaneous release of platelets
Stem cells were isolated from the umbilical cord matrix and grown in culture for 14 days. At this stage most cells in the population are at the mature megakaryocyte stage and can start producing platelets in internal membranes present in their cytoplasm. In this...
Feature Client: Michal Cifra from the Institute of Photonics and Electronics Academy of Sciences (Czech Republic)
Dr. Michal Cifra is the young, dynamic team leader of the Bioelectrodynamics team at the Institute of Photonics and Electronics Academy of Sciences (Czech Republic). His lab has recently purchased Nanolive’s 3D Cell Explorer-fluo microscope and published his first...
Antibodies being used as a T-cell targeting system to wipe out cancer cells
Nanolive’s automated microscope, the CX-A, allows scientists to monitor dynamic interactions between immune cells and cancer cells at the population level, unperturbed, and with zero phototoxicity involved. Here, the CX-A was used to visualize whether the addition of...
Feature Client: Patrick Sandoz from the KTH Royal Institute of Technology (Stockholm, Sweden)
Dr. Patrick Sandoz has been collaborating with Nanolive since 2013, first as a PhD student and then as a post-doc in Prof. van der Goot’s lab at EPFL (Lausanne, Switzerland). He played a very important role in testing Nanolive’s first microscope, the 3D Cell Explorer....
Papillomavirus infection in HeLa cells
Human papillomavirus (HPV) is the most common viral sexually transmitted disease [1]. Most sexually active individuals will become infected at some point in their lives. Of those infections, about 90% are asymptomatic and resolve spontaneously [1]. Additionally, some...
Nanolive imaging used to distinguish morphological traits of mutant cancer cells
We are delighted to announce that a new publication featuring Nanolive imaging has been published in BMC Molecular and Cell Biology. The study, a huge international collaboration spearheaded by Dr. Michael Cahill from the Charles Sturt University (NSW, Australia) and...
Nanolive Imaging enables scientists to study how different viruses infect living cells
Dr. Yakimovich and colleagues from the Greber group based at the University of Zurich, published a scientific paper that described how Nanolive imaging can be used to visualize the cytopathic (structural changes) effects that different viruses have on host cells...
3 new scientific publications using Nanolive imaging
We are delighted to announce that three new scientific articles have been published using Nanolive’s 3D Cell Explorer. The articles come from users based in Prague (Czech Republic), Bern (Switzerland) and Vienna (Austria), respectively. Proinflammatory Effect of...
Is it possible to restore phagocytosis of cancer cells?
CD47 is a potent Don’t eat me signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages. By using bispecific antibodies with a high affinity targeting arm (against a tumor-associated antigen, or TAA) and an...
Can the use of saturated fatty acids improve lipid drug delivery systems?
We are happy to feature a new publication from users of Nanolive’s 3D Cell Explorer, located at the AGH University of Science and Technology (Kraków, Poland) and The University of Sydney (Australia). The effect of saturated fatty acids (FAs) on malignant and...
Nanolive technology reveals ferroptosis execution in an aggressive human prostate cancer model
Ferroptosis is a new type of regulated cell death that was formally identified in 2012 [1]. It is an iron-dependent, non-apoptotic mode of cell death that is strongly linked to lipid metabolism. Since its discovery, Ferroptosis has been identified as a key regulator...
Nanolive technology highlights the importance of wnt signaling in organoid self-organization
Cell-cell interactions between embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) play a vital role in tissue formation in developing embryos [1]. The two cell types are known to communicate through the wnt/β-catenin signaling pathway [2], but identifying...
Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes
Could Mitochondrial transplantation into Cardiomyocytes be an effective treatment for cardiac disease? This paper shows the first test of transplanting non-autologous mitochondria from healthy skeletal muscle cells into normal cardiomyocytes. This transplant led to...