CD47 is a potent Don’t eat me signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages.
By using bispecific antibodies with a high affinity targeting arm (against a tumor-associated antigen, or TAA) and an anti CD47 arm of an optimized low affinity, the Don’t eat me signal is blocked selectively on TAA-positive cells, leading to the effective engulfment and degradation of tumor cells by macrophages (left-hand part of the video).
Due to the absence of a tumor-specific targeting arm, a monovalent anti CD47 bsAb is unable to bind and block CD47, with tumor cells that can resist the attack of macrophages (right-hand part of the video).
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We have 11 new publications featuring Nanolive imaging to round-up the end of 2022, and one to welcome 2023! Find links to all twelve papers on topics from mitochondria, to neutrophils, leukemia, red blood cells, and bacteria below.We really saw an increase in groups...
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Upcoming Webinar – The LIVE Cell Death Assay: Drug discovery applications of cell health, stress, death, and recovery analyses
Showcasing our AI-powered digital cytotoxicity and cell viability assay, we will explore how Nanolive's high-content live cell imaging can be used to increase confidence in lead candidate selection.We will explore the following drug discovery applications of...
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