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  • Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy

    Authors: Nam Gyu Im; Amy Guillaumet-Adkins; Megha Wal; Anna J. Rogers; Julia Frede; Claire C. Havig; Jing Yang; Praveen Anand; Sarah K. Stegmann; Johannes M. Waldschmidt; Noori Sotudeh; Leili Niu; Jordan Voisine; Michal R. Schweiger; Clemens Grassberger; Jens G. Lohr; Birgit Knoechel

    https://doi.org/10.1158/2326-6066.CIR-21-0626, 2022

    Published in: Cancer Immunology Research

    Tags: CD19; CAR-T; B-cell acute lymphoblastic leukemia; transcriptional plasticity

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  • Breast radiotherapy with kilovoltage photons and gold nanoparticles as radiosensitizer: An in vitro study

    Authors: Alessia Tudda; Elisabetta Donzelli; Gabriella Nicolini; Sara Semperboni; Mario Bossi; Guido Cavaletti; Roberta Castriconi; Paola Mangili; Antonella del Vecchio; Antonio Sarno; Giovanni Mettivier; Paolo Russo

    https://doi.org/10.1002/mp.15348, 2021

    Published in: Medical Physics

    Tags: breast cancer, breast radiotherapy, gold nanoparticles, kilovoltage radiotherapy

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  • Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer

    Authors: Lu Lu; He Zhang; Yudong Zhou; Jiayi Lin; Weidong Gao; Ting Yang; Jinmei Jin; Lijun Zhang; Dale G. Nagle; Weidong Zhang; Ye Wu; Hongzhuan Chen; Xin Luan

    https://doi.org/10.7150/thno.71129, 2022

    Published in: Theranostics

    Tags: colorectal cancer, stapled mastoparan peptide, peptide-polymer conjugate, immunogenic cell death, oncolytic immunotherapy

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  • Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines

    Authors: Maria do Carmo Greier; Annette Runge; Jozsef Dudas; Viktoria Pider; Ira-Ida Skvortsova; Dragana Savic; Herbert Riechelmann

    https://doi.org/10.1038/s41598-022-16829-5, 2022

    Published in: Scientific Reports

    Tags: mitochondria; mesenchymal stem cells; head neck cancer

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  • Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen receptor-positive breast cancer

    Authors: Johanna M. Buschhaus, Shrila Rajendran, Brock A. Humphries, Alyssa C. Cutter, Ayşe J. Muñiz, Nicholas G. Ciavattone, Alexander M. Buschhaus, Tatiana Cañeque, Zeribe C. Nwosu, Debashis Sahoo, Avinash S. Bevoor, Yatrik M. Shah, Costas A. Lyssiotis, Pradipta Ghosh, Max S. Wicha, Raphaël Rodriguez, Gary D. Luker

    https://doi.org/10.1038/s41388-022-02385-9, 2022

    Published in: Oncogene

    Tags: breast cancer, stem cells, iron, lysosome, drug resistance, estrogen-targeted therapy

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  • Technical Note: Live T Cell Assay

    This technical note explores these challenges, and presents Nanolive’s cutting edge, AI-assisted solution, the Live T Cell Assay. It also includes a full use case study where the Live T Cell Assay is used to quantify the effect a bispecific antibody has on T cell and cancer cell dynamics.

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  • Feature Application: Live T Cell Assay

    The Live T Cell Assay promises to accelerate the advancement of basic cell biology and of novel, safe, and effective immunotherapies. The goal of this application note is to show some of the potential uses of the Live T Cell Assay and hopefully, inspire research that will increase the success rate of anticancer drug development. To this end, we present the first in-depth investigation of bispecific antibodies using the Live T Cell Assay.

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  • Feature Application: Multiparametric cytotoxicity assays

    This Feature Application shows the huge potential that Nanolive imaging holds for the drug discovery process, where cytotoxicity remains one of the major causes of drug withdrawal, and there is an urgent need for reliable and time-saving assay workflows. Our first case study features an in-depth investigation of the dynamics of cell death following exposure to seven cell death stimuli: extreme shifts in external pH, thermal stress, phototoxicity, oxidative stress, Shikonin, Ebastine, and Taxol. Our second case study shows that we can quantify drug-dependent and dose-dependent effects in 96-well plate format.

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  • Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy

    Authors: Paola Bonaventura; Vincent Alcazer; Virginie Mutez; Laurie Tonon; Juliette Martin; Nicolas Chuvin; Emilie Michel; Rasha E. Boulos; Yann Estornes; Jenny Valladeau-Guilemond; Alain Viari; Qing Wang; Christophe Caux; Stéphane Depil

    https://doi.org/10.1126/sciadv.abj3671, 2022

    Published in: Science Advances

    Tags: adaptive immunity; Human endogenous retroviruses; cancer vaccine; immunotherapy; solid tumors

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  • AlPc/ZnPc-based oncological photodynamic therapy for a selective eradication of leukemic cells from ovarian tissue

    Authors: Saeid Moghassemi; Arezoo Dadashzadeh; Paulo Eduardo Narcizode Souza; Ricardo Bentes Azevedo; Christiani A. Amorim

    https://doi.org/10.1016/j.pdpdt.2021.102555, 2021

    Published in: Photodiagnosis and Photodynamic Therapy

    Tags: Photodynamic therapy; cancer therapy; photosensitizer; ovarian transplantation; leukemia; phthalocyanine; photoimmunotherapy

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