Scientific Publications

Authors: Lu Lu; He Zhang; Yudong Zhou; Jiayi Lin; Weidong Gao; Ting Yang; Jinmei Jin; Lijun Zhang; Dale G. Nagle; Weidong Zhang; Ye Wu; Hongzhuan Chen; Xin Luan

https://doi.org/10.7150/thno.71129, 2022

Published in: Theranostics

Tags: colorectal cancer, stapled mastoparan peptide, peptide-polymer conjugate, immunogenic cell death, oncolytic immunotherapy

Authors: Maria do Carmo Greier; Annette Runge; Jozsef Dudas; Viktoria Pider; Ira-Ida Skvortsova; Dragana Savic; Herbert Riechelmann

https://doi.org/10.1038/s41598-022-16829-5, 2022

Published in: Scientific Reports

Tags: mitochondria; mesenchymal stem cells; head neck cancer

Authors: Johanna M. Buschhaus, Shrila Rajendran, Brock A. Humphries, Alyssa C. Cutter, Ayşe J. Muñiz, Nicholas G. Ciavattone, Alexander M. Buschhaus, Tatiana Cañeque, Zeribe C. Nwosu, Debashis Sahoo, Avinash S. Bevoor, Yatrik M. Shah, Costas A. Lyssiotis, Pradipta Ghosh, Max S. Wicha, Raphaël Rodriguez, Gary D. Luker

https://doi.org/10.1038/s41388-022-02385-9, 2022

Published in: Oncogene

Tags: breast cancer, stem cells, iron, lysosome, drug resistance, estrogen-targeted therapy

This technical note explores these challenges, and presents Nanolive’s cutting edge, AI-assisted solution, the Live T Cell Assay. It also includes a full use case study where the Live T Cell Assay is used to quantify the effect a bispecific antibody has on T cell and cancer cell dynamics.

The Live T Cell Assay promises to accelerate the advancement of basic cell biology and of novel, safe, and effective immunotherapies. The goal of this application note is to show some of the potential uses of the Live T Cell Assay and hopefully, inspire research that will increase the success rate of anticancer drug development. To this end, we present the first in-depth investigation of bispecific antibodies using the Live T Cell Assay.

This Feature Application shows the huge potential that Nanolive imaging holds for the drug discovery process, where cytotoxicity remains one of the major causes of drug withdrawal, and there is an urgent need for reliable and time-saving assay workflows. Our first case study features an in-depth investigation of the dynamics of cell death following exposure to seven cell death stimuli: extreme shifts in external pH, thermal stress, phototoxicity, oxidative stress, Shikonin, Ebastine, and Taxol. Our second case study shows that we can quantify drug-dependent and dose-dependent effects in 96-well plate format.

Authors: Paola Bonaventura; Vincent Alcazer; Virginie Mutez; Laurie Tonon; Juliette Martin; Nicolas Chuvin; Emilie Michel; Rasha E. Boulos; Yann Estornes; Jenny Valladeau-Guilemond; Alain Viari; Qing Wang; Christophe Caux; Stéphane Depil

https://doi.org/10.1126/sciadv.abj3671, 2022

Published in: Science Advances

Tags: adaptive immunity; Human endogenous retroviruses; cancer vaccine; immunotherapy; solid tumors

Authors: Saeid Moghassemi; Arezoo Dadashzadeh; Paulo Eduardo Narcizode Souza; Ricardo Bentes Azevedo; Christiani A. Amorim

https://doi.org/10.1016/j.pdpdt.2021.102555, 2021

Published in: Photodiagnosis and Photodynamic Therapy

Tags: Photodynamic therapy; cancer therapy; photosensitizer; ovarian transplantation; leukemia; phthalocyanine; photoimmunotherapy

Authors: Ana Luisa Palacios-Acedo; Soraya Mezouar; Diane Mège; Lydie Crescence; Christophe Dubois; Laurence Panicot-Dubois

https://doi.org/10.3389/fonc.2021.704945, 2021

Published in: Frontiers in Oncology

Tags: pancreatic tumors; thrombosis; clopidogrel; aspirin; P2Y12 receptor

Authors: Francesca Carriero; Carolina Martinelli; Fabio Gabriele; Giulia Barbieri; Lisa Zanoletti; Gloria Milanesi; Claudio Casali; Alberto Azzalin; Federico Manai; Mayra Paolillo; Sergio Comincini

https://doi.org/10.3390/jpm11100942, 2021

Published in: Journal of Personalized Medicine

Tags: oxidative stress; phyto-therapy; astrocytoma; glial tumor