Scientific Publications

Peer-reviewed research using Nanolive imaging

Discover a list of peer-reviewed scientific publications using Nanolive imaging in the fields of drug discovery, cell metabolism, etc.

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  • Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous Carcinoma

    Authors: Che-Fang Hsu, Pao-Chu Chen, Vaishnavi Seenan, Dah-Ching Ding, Tang-Yuan Chu 

    https://doi.org/10.3390/cancers13030468, 2021

    Published in: Cancers

    Tags: follicular fluid; high-grade serous carcinoma; Fallopian tube; transformation; peritoneal metastasis

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  • Oxidative Effects during Irreversible Electroporation of Melanoma Cells – In Vitro Study

    Authors: Wojciech Szlasa, Aleksander Kiełbik, Anna Szewczyk, Nina Rembiałkowska, Vitalij Novickij, Mounir Tarek, Jolanta Saczko, Julita Kulbacka

    https://doi.org/10.3390/molecules26010154, 2021

    Published in: Molecules

    Tags: IRE; oxidative stress; melanoma; permeabilization; membrane alternations

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  • Electrochemotherapy with Calcium Chloride and 17-Estradiol Modulated Viability and Apoptosis Pathway in Human Ovarian Cancer

    Authors: Zofia Łapińska, Michał Debiński, Anna Szewczyk, Anna Choromańska, Julita Kulbacka, Jolanta Saczko

    https://doi.org/10.3390/pharmaceutics13010019, 2021

    Published in: Pharmaceutics

    Tags: 17-estradiol; chemotherapy; electrochemotherapy; calcium electroporation; ovarian cancer; MDAH-2774

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  • Effects of curcumin based PDT on the viability and the organization of actin in melanotic (A375) and amelanotic melanoma (C32)– in vitro studies

    Authors: Wojciech Szlasa, Stanisław Supplitt, Małgorzata Drąg-Zalesińska, Dawid Przystupski, Krzysztof Kotowski, Anna Szewczyk, Paulina Kasperkiewicz, Jolanta Saczko, Julita Kulbacka

    https://doi.org/10.1016/j.biopha.2020.110883, 2020

    Published in: Biomedicine & Pharmacotherapy

    Tags: curcumin; melanoma; photodynamic therapy; apoptosis; motility

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  • Tumor vessel targeted self-assemble nanoparticles for amplification and prediction of the embolization effect in hepatocellular carcinoma

    Authors: Yaqin Wang, Wenting Shang, Hongshan Zhong, Ting Luo, Meng Niu, Ke Xu, Jie Tian

    https://doi.org/10.1021/acsnano.0c04341, 2020

    Published in: ACS Nano

    Tags: coagulation cascade; tumor embolism; vessel density; hepatocellular carcinoma; self-assemble; nanoparticle

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  • Apoptosis as the main type of cell death induced by calcium electroporation in rhabdomyosarcoma cells

    Authors: Anna Szewczyk, Jolanta Saczko, Julita Kulbacka

    DOI: https://doi.org/10.1016/j.bioelechem.2020.107592, 2020 

    Published in: Bioelectrochemistry

    Tags: rhabdomyosarcoma, muscle cells, calcium ions, electroporation, caspase 3, apoptosis

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  • Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1

    Authors: Kuan-Chou Chen, Chang-Rong Chen, Chang-Yu Chen, Kai-Yi Tzou, Chiung-Chi Peng, Robert Y. Peng

    DOI: https://doi.org/10.21873/anticanres.14232, 2020

    Published in: Anticancer Research

    Tags: Oncology and immunooncology, cell metabolism, CX, PC-3 Pca, bicalutamide, Bic, rat mesangial cell, RMC line, mitochondrial dysfunction, HIF-1, oxygen consumption rate, OCR, mitochondria, pgrostate cancer, Pca, cardiovascular damage, renal damage, lactate cehydrogenase, ROS, lysosome, BCL2, caspase-3

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  • The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells

    Authors: Chien-HanYuan, Yi-LingMa, Po-ChangShih, Chao-TingChen, Shu-YuCheng, Chieh-YuPan, Yen-HsuanJean, Yih-MinChu, Sung-ChunLin, Yu-ChengLai, Hsiao-MeiKuo

    DOI: https://doi.org/10.21873/anticanres.14232, 2020

    Published in: Biochemical Pharmacology

    Tags: Immunooncology, oncology, cell metabolism, OS MG63, osteosarcoma, intrinsic apoptosis, TP3, antimicrobial peptide, mitochondria, caspase, blebbing, shrinkage, nuclear fragmentation, chromatin condensation, apoptopodia, ROS, acidification, fission, fusion

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  • Feature Application: Characterising cancer cells and their interactions with immune cells

    In this application note, we begin by examining the interactions between t-cells, dendritic cells, and macrophages (case study 1). We then image t-cells responses to cancer cells (case study 2) and the interactions that occur between t-cells and macrophages (case study 3). We show Nanolive imaging can be used to monitor the response of cancer cells to promising antibody drug conjugate (ADCs) products (case study 4) and novel bispecific antibodies (case studies 5 and 6). Finally, we finish with an example of a drug screen where we describe the phenotypic response of living cells to various kinase inhibitors that have shown promise as anti-cancer treatments (case study 7).

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  • 3PO as a Selective Inhibitor of 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 in A375 Human Melanoma Cells

    Authors: Kotowski K, Supplitt S, Wiczew D, Przystupski D, Bartosik W, Saczko J, Rossowska J, Drąg-Zalesińska M, Michel O, Kulbacka J.

    DOI: https://doi.org/10.21873/anticanres.14232, 2020

    Published in: Anticancer Research

    Tags: Immunooncology and oncology, B-raf kinase, 3PO, A375, BRAFV600E, Melanoma, PFKFB3, inhibitor, apoptosis, glucose uptake, cycle arrest

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