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  • ATP synthase is essential for high conductance but not low conductance Mitochondrial Permeability Transition

    Authors: M.A. Neginskaya; S.E. Morris; E.V. Pavlov

    https://doi.org/10.1101/2021.11.16.468842, 2022

    Published in: bioRxiv

    Tags: mitochondria; ATP synthase; MTP

  • Feature Application: Characterization of single cells at the population level

    In this Feature Application, we showcase the enormous potential that Nanolive live cell imaging holds for single cell characterization. We begin, by analyzing micro-heterogeneity at the population and the temporal level in unperturbed cells (case study one). We then extend our analysis to include a quantitative assessment of lipid droplet dynamics (case study two), before investigating how intracellular trafficking (case study three) and respiratory perturbation (case study four) impacts microheterogeneity in cell morphology.

  • Modulation of mitochondrial electron transport chain by pyroptosis nanoagonists for photoresponsive tumor destruction

    Authors: Penghao Ji, Shenyan Zhang, Peilei Liu, Xi Li, Weichao Bao, Xiangzhi Cui, Minfeng Huo, Jianlin Shi

    https://doi.org/10.1016/j.nantod.2022.101511, 2022

    Published in: Nanotoday

    Tags: Pyroptosis; Oligomycin A; Mitochondrial damage; Oxidative stress; Mild hyperthermia

  • Mitochondrial Dynamics in SARS‑COV2 Spike Protein Treated Human Microglia: Implications for Neuro‑COVID

    Authors: Erin Clough; Khoo Ting Chean; Joseph Inigo; Kate E. Tubbesing; Dhyan Chandra; Lee Chaves; Jessica L. Reynolds; Ravikumar Aalinkeel; Stanley A. Schwartz; Alexander Khmaladze; Supriya D. Mahajan

    https://doi.org/10.1007/s11481-021-10015-6, 2021

    Published in: Journal of Neuroimmune Pharmacology

    Tags: SARS-COV2; Microglia; Neuro-inflammation; Oxidative stress; Mitochondrial dysfunction; Neuro-COVID

  • Mitochondrial Transplantation in Cardiomyocytes: foundation, methods, and outcomes

    Authors: Paria Ali Pour; Sina Hosseinian; Arash Kheradvar

    https://doi.org/10.1152/ajpcell.00152.2021, 2021

    Published in: American Journal of Physiology: Cell Physiology

    Tags: mitochondrial transplantation; mitochondrial transfer, mitochondrial diseases, mitochondrial cardiomyopathy, ischemia reperfusion injury, bioenergetics

  • Low biological fluctuation of mitochondrial CpG and non‑CpG methylation at the single‑molecule level

    Authors: Chloe Goldsmith, Jesús Rafael Rodríguez-Aguilera, Ines El-Rifai, Adrien Jarretier, Valérie Hervieu, Victoria Chagoya de Sánchez, Robert Dante, Gabriel Ichim, Hector Hernandez-Vargas

    https://doi.org/10.1038/s41598-021-87457-8, 2021

    Published in: Scientific Reports

    Tags: Nanopore sequencing; DNA methylation; mtDNA; metabolism; hepatocytes; differentiation; oxidative stress; 5mC; long-read sequencing

  • NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases

    Authors: M.W. Park, H.W. Cha, J. Kim, J.H. Kim, H. Yang, S. Yoon, N. Boonpraman, S.S. Yi, I.D. Yoo, J.-S. Moon

    https://doi.org/10.1016/j.redox.2021.101947, 2021

    Published in: Redox Biology

    Tags: NOX4, Ferroptosis, Mitochondrial metabolism, Oxidative stress, Alzheimer’s disease

  • Biological autoluminescence as a noninvasive monitoring tool for chemical and physical modulation of oxidation in yeast cell culture

    Authors: Martin Bereta, Michal Teplan, Djamel Eddine Chafai, Roman Radil, Michal Cifra

    https://doi.org/10.1038/s41598-020-79668-2, 2021

    Published in: Scientific Reports

    Tags: biological autoluminescence (BAL); Saccharomyces cerevisiae; Fenton reagents; cell metabolism

  • Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

    Authors: Pascal D OdermattTeemu P Miettinen Joël Lemière Joon Ho Kang Emrah Bostan Scott R Manalis Kerwyn Casey Huang Fred Chang

    https://doi.org/10.7554/eLife.64901, 2021

    Published in: eLife

    Tags: cell cycle; dry-mass; cell cycle arrest; osmosis

  • Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause

    Authors: E. Ouni, C. Bouzin, M.M. Dolmans, E. Marbaix, S. Pyr dit Ruys, D. Vertommen, C.A. Amorim

    DOI: https://doi:10.1093/humrep/deaa100, 2020

    Published in: Human Reproduction

    Tags: Ovary, extracellular matrix, hormone replacement therapy, CX, aging, fertility preservation, mechanobiology, elastic matrisome, matrisome, collagen, elastin, EMILIN-1, fiblilin-1, glycosaminoglycan, GAGs, folicle, ECM