Scientific Publications

Peer-reviewed research using Nanolive imaging

Discover a list of peer-reviewed scientific publications using Nanolive imaging in the fields of drug discovery, cell metabolism, etc.

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Displaying 39 results:

  • Preparation of a camptothecin analog FLQY2 self‑micelle solid dispersion with improved solubility and bioavailability

    Authors: Yi Wang; Wenchao Wang; Endian Yu; Wenya Zhuang; Xuanrong Sun; Hong Wang; Qingyong Li

    https://doi.org/10.1186/s12951-022-01596-2, 2022

    Published in: Journal of Nanobiotechnology

    Tags: Camptothecin, Soluplus®, Solid dispersion, Micelle, Solubility, Pharmacokinetics, In vivo antitumor activity

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  • Early Pharmacological Profiling of Antiproliferative Compounds by Live Cell Imaging

    Authors: Adrián Puerta; Aday González-Bakker; Guido Santos; José M. Padrón

    https://doi.org/10.3390/molecules27165261, 2022

    Published in: Molecules

    Tags: phenotypic drug discovery; cancer; natural products; live cell imaging; machine learning; antimitotic drugs; microtubule binding drugs

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  • Feature Application: Calculating kinetic EC50 values from dose-response curves

    The non-invasive nature of label-free imaging means cells can be continuously monitored, over infinite periods of time, which means kinetic EC50 values can also be calculated. Time-dependent EC50 values provide information about drug stability; whether a drug’s potency increases or decreases over time. In this application note we show how to calculate kinetic EC50 values from data directly output from Nanolive’s image analysis software, EVE Analytics.

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  • Feature Application: Multiparametric cytotoxicity assays

    This Feature Application shows the huge potential that Nanolive imaging holds for the drug discovery process, where cytotoxicity remains one of the major causes of drug withdrawal, and there is an urgent need for reliable and time-saving assay workflows. Our first case study features an in-depth investigation of the dynamics of cell death following exposure to seven cell death stimuli: extreme shifts in external pH, thermal stress, phototoxicity, oxidative stress, Shikonin, Ebastine, and Taxol. Our second case study shows that we can quantify drug-dependent and dose-dependent effects in 96-well plate format.

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  • Legumain/pH dual-responsive lytic peptide–paclitaxel conjugate for synergistic cancer therapy

    Authors: Shanshan Zheng, Yue Cai, Yulu Hong, Yubei Gong, Licheng Gao, Qingyong Li, Le Li, Xuanrong Sun

    https://doi.org/10.1080/10717544.2022.2081380, 2022

    Published in: Drug Delivery

    Tags: Peptide–drug conjugate; legumain-responsive; pH-responsive; synergistic cancer therapy

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  • Effects of Glycyrrhizin on Multi-Drug Resistant Pseudomonas aeruginosa

    Authors: Nicholas J. Carruthers, Sharon A. McClellan, Mallika Somayajulu, Ahalya Pitchaikannu, Denise Bessert, Xudong Peng, Kylie Huitsing, Paul M. Stemmer and Linda D. Hazlett

    https://doi.org/10.3390/pathogens9090766, 2020

    Published in: Pathogens

    Tags: Pseudomonas aeruginosa; glycyrrhizin; multi-drug resistance; proteomics

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  • Protein corona determines the cytotoxicity of nanodiamonds implications of corona formation and its remodelling on nanodiamond applications in biomedical imaging and drug delivery

    Authors: Dipesh Khanal, Qingyu Lei, Gabriela Pinget, Daniel A. Cheong, Archana Gautam, Ridhwan Yusoff, Bowyn Su, Seiji Yamaguchi, Alexey Kondyurin, Jonathan C. Knowles, George Georgiou, Laurence Macia, Jun-Hyeog Jang, Iqbal Ramzan, Kee Woei Ng, Wojciech Chrzanowski

    DOI: https://doi.org/10.1039/D0NA00231C, 2020 

    Published in: Nanoscale Advances

    Tags: nanodiamonds; drug delivery; protein corona; nanoparticles; macrophages

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  • Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

    Authors: Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl , Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch

    DOI: https://doi.org/10.3390/ijms21134808, 2020 

    Published in: International Journal of Molecular Sciences

    Tags: myeloid cells; primitive macrophages; induced pluripotent stem cells; in vitro characterization; drug discovery; disease modeling

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  • BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

    Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

    DOI: https://doi.org/10.1117/1.JBO.24.4.046503, 2019

    Published in: Journal of Biomedical Optics

    Tags: Single cell characterization, drug discovery, neuroscience, rat, C6 glial cells, methamphetamine, Raman spectroscopy, apoptosis

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  • Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells

    Authors: Diana Díaz-García, Lucia Sommerova, Andrea Martisova, Hana Skoupilova, Sanjiv Prashar, Tomas Vaculovic, Viktor Kanicky, Isabel del Hierro, Roman Hrstka, Santiago Gómez-Ruiz

    DOI: https://doi.org/10.1016/j.micromeso.2020.110154, 2020

    Published in: Microporous and Mesoporous Materials

    Tags: Drug discovery, immunooncology & oncology, 

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