Scientific Publications
Peer-reviewed research using Nanolive imagingDiscover a list of peer-reviewed scientific publications using Nanolive imaging in the fields of drug discovery, cell metabolism, etc.
Displaying 22 results:
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Feature Application: Characterization of neurons
This Feature Application shows the huge potential that Nanolive cell imaging holds for neurobiological research. Our first case study shows a timeline of the morphological changes undifferentiated primary cortical neurons undergo after exposure to neurite stimulation media. High precision segmentations are used to calculate cell metrics (e.g. volume, shape and dry mass) of interest. These calculations are directly linked to novel behaviours observed in individual neurons. Our second and third case studies focus on the sub-cellular morphological changes that stem cells undergo during neural differentiation, at both the single cell (case study 2) and population level (case study 3).
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Occurrence of lymphangiogenesis in peripheral nerve autografts contrasts Schwann cell-induced apoptosis of lymphatic endothelial cells in vitro
Authors: Carina Hromada, Jaana Hartmann, Johannes Oesterreicher, Anton Stoiber, Anna Daerr, Barbara Schädl, Eleni Priglinger, Andreas H. Teuschl-Woller, Wolfgang Holnthoner, Johannes Heinzel, David Hercher
https://doi.org/10.3390/biom12060820, 2022
Published in: Biomolecules
Tags: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells
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Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection
Authors: Shun Li, Florian olde Heuvel, Rida Rehman, Zhenghui Li, Oumayma Aousji, Albrecht Froehlich, Wanhong Zhang, Alison Conquest, Sarah Woelfle, Michael Schoen, Caitlin O´Meara, Richard Lee Reinhardt, David Voehringer, Jan Kassubek, Albert Ludolph, Markus Huber-Lang, Bernd Knöll, Maria Cristina Morganti-Kossmann, Tobias Boeckers, Francesco Roselli
https://doi.org/10.1101/2021.12.01.470746, 2021
Published in: bioRxiv
Tags: IL-13, synapses, CREB, excitotoxicity, traumatic brain injury
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Elevated CLOCK and BMAL1 contribute to the impairment of aerobic glycolysis from astrocytes in Alzheimer’s disease
Authors: Ik Dong Yoo, Min Woo Park, Hyeon Woo Cha, Sunmi Yoon, Napissara Boonpraman, Sun Shin Yi, Jong-Seok Moon
https://doi.org/10.3390/ijms21217862, 2020
Published in: International Journal of Molecular Sciences
Tags: CLOCK; BMAL1; aerobic glycolysis; astrocytes; Alzheimer’s disease
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Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1
Authors: John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rose M. De Guzman, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander Khmaladze, Alexey Semyanov, Damian G. Zuloaga, Michele Migliore, Annalisa Scimemi
https://doi.org/10.1016/j.celrep.2020.108255, 2020
Published in: Cell Reports
Tags: circadian rhythmicity; NMDA receptors; corticosterone; cognitive processing; hippocampal neurons
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BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells
Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze
DOI: https://doi.org/10.1117/1.JBO.24.4.046503, 2019
Published in: Journal of Biomedical Optics
Tags: Single cell characterization, drug discovery, neuroscience, rat, C6 glial cells, methamphetamine, Raman spectroscopy, apoptosis
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TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment
Authors: Ying-Fa Chen, Po-Chang Shih, Hsiao-Mei Kuo, San-Nan Yang, Yen-You Lin, Wu-Fu Chen, Shiow-Jyu Tzou, Hsin-Tzu Liu and Nan-Fu Chen
DOI: https://doi.org/10.1002/cam4.3005, 2020
Published in: Cancer Medicine
Tags: Immunooncology and oncology, neuroscience, cell mobility, glioblastoma multiforme, infiltration, TP3, tumor microenvironment, adhesion, migration, invasion, invasiveness, filopodia, cell attachment, metastasis, kinase, paxillin, RAS, AKT, ERK, JNK, p38
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Advancing methods for the analysis of glioblastoma cell motion using quantitative time lapse holographic imaging and cellular tomography
Authors: Ed Luther, Livia Mendes, Nina Filiczak, Aditi Jhaveri, Lara Milane, Vladimir Torchilin
DOI: https://doi.org/10.1117/12.2510236, 2019
Published in: Society of Photo-Optical Instrumentation Engineers
Tags: Neuroscience, Immunooncology & Oncology, mitochondria and cell metabolism, glioblastoma, motility, mitochondria, fission, fusion, nanotubes, spheroids
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Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling
Authors: Hyunsook Kang, Seong Jun Choi, Kye Hoon Park, Chi-Kyou Lee, and Jong-Seok Moon
DOI: https://doi.org/DOI: 10.3390/ijms21020476, 2020
Published in: International Journal of Molecular Sciences
Tags: Neuroscience, single cell characterization, mitochondria and cell metabolism, glycolysis, EGFR signaling, apoptosis, alcohol, HEI-OC1 cells, glucose metabolism, glucose, auditory sytem, apoptosis, hexokinase 1, HK1, AKT phosphorylation
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Beyond the suprachiasmatic nucleus: circadian rhythmicity shapes astrocyte morphology and neuronal function in hippocampal area CA1
Authors: John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander Khmaladze, Alexey Semyanov, Michele Migliore and Annalisa Scimemi
DOI: https://doi.org/10.1101/666073, 2019
Published in: bioRxiv
Tags: Neuroscience, single cell characterization, suprachiasmatic nucleus, SCN, hypothalamus, rhythmic activity, memory-dependent, hippocampus, CA1, circadian rhythmicity, synaptic transmission, pyramidal neurons, NMDA receptors, astrocytes