Scientific Publications
Peer-reviewed research using Nanolive imagingDiscover a list of peer-reviewed scientific publications using Nanolive imaging in the fields of drug discovery, cell metabolism, etc.
Displaying 42 results:
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Modulation of mitochondrial electron transport chain by pyroptosis nanoagonists for photoresponsive tumor destruction
Authors: Penghao Ji, Shenyan Zhang, Peilei Liu, Xi Li, Weichao Bao, Xiangzhi Cui, Minfeng Huo, Jianlin Shi
https://doi.org/10.1016/j.nantod.2022.101511, 2022
Published in: Nanotoday
Tags: Pyroptosis; Oligomycin A; Mitochondrial damage; Oxidative stress; Mild hyperthermia
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Mitochondrial Dynamics in SARS‑COV2 Spike Protein Treated Human Microglia: Implications for Neuro‑COVID
Authors: Erin Clough; Khoo Ting Chean; Joseph Inigo; Kate E. Tubbesing; Dhyan Chandra; Lee Chaves; Jessica L. Reynolds; Ravikumar Aalinkeel; Stanley A. Schwartz; Alexander Khmaladze; Supriya D. Mahajan
https://doi.org/10.1007/s11481-021-10015-6, 2021
Published in: Journal of Neuroimmune Pharmacology
Tags: SARS-COV2; Microglia; Neuro-inflammation; Oxidative stress; Mitochondrial dysfunction; Neuro-COVID
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Eimeria bovis macromeront formation induces glycolytic responses and mitochondrial changes in primary host endothelial cells
Authors: Zahady D. Velásquez; Sara López-Osorio; Sybille Mazurek; Carlos Hermosilla; Anja Taubert
https://doi.org/10.3389/fcimb.2021.703413, 2021
Published in: Frontiers in Cellular and Infection Microbiology
Tags: apicomplexan parasites; Eimeria bovis; endothelial cell; senescence; mitochondrial damage; reactive oxygen products
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Mitochondrial Transplantation in Cardiomyocytes: foundation, methods, and outcomes
Authors: Paria Ali Pour; Sina Hosseinian; Arash Kheradvar
https://doi.org/10.1152/ajpcell.00152.2021, 2021
Published in: American Journal of Physiology: Cell Physiology
Tags: mitochondrial transplantation; mitochondrial transfer, mitochondrial diseases, mitochondrial cardiomyopathy, ischemia reperfusion injury, bioenergetics
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Low biological fluctuation of mitochondrial CpG and non‑CpG methylation at the single‑molecule level
Authors: Chloe Goldsmith, Jesús Rafael Rodríguez-Aguilera, Ines El-Rifai, Adrien Jarretier, Valérie Hervieu, Victoria Chagoya de Sánchez, Robert Dante, Gabriel Ichim, Hector Hernandez-Vargas
https://doi.org/10.1038/s41598-021-87457-8, 2021
Published in: Scientific Reports
Tags: Nanopore sequencing; DNA methylation; mtDNA; metabolism; hepatocytes; differentiation; oxidative stress; 5mC; long-read sequencing
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NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases
Authors: M.W. Park, H.W. Cha, J. Kim, J.H. Kim, H. Yang, S. Yoon, N. Boonpraman, S.S. Yi, I.D. Yoo, J.-S. Moon
https://doi.org/10.1016/j.redox.2021.101947, 2021
Published in: Redox Biology
Tags: NOX4, Ferroptosis, Mitochondrial metabolism, Oxidative stress, Alzheimer’s disease
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Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1
Authors: Kuan-Chou Chen, Chang-Rong Chen, Chang-Yu Chen, Kai-Yi Tzou, Chiung-Chi Peng, Robert Y. Peng
DOI: https://doi.org/10.21873/anticanres.14232, 2020
Published in: Anticancer Research
Tags: Oncology and immunooncology, cell metabolism, CX, PC-3 Pca, bicalutamide, Bic, rat mesangial cell, RMC line, mitochondrial dysfunction, HIF-1, oxygen consumption rate, OCR, mitochondria, pgrostate cancer, Pca, cardiovascular damage, renal damage, lactate cehydrogenase, ROS, lysosome, BCL2, caspase-3
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The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells
Authors: Chien-HanYuan, Yi-LingMa, Po-ChangShih, Chao-TingChen, Shu-YuCheng, Chieh-YuPan, Yen-HsuanJean, Yih-MinChu, Sung-ChunLin, Yu-ChengLai, Hsiao-MeiKuo
DOI: https://doi.org/10.21873/anticanres.14232, 2020
Published in: Biochemical Pharmacology
Tags: Immunooncology, oncology, cell metabolism, OS MG63, osteosarcoma, intrinsic apoptosis, TP3, antimicrobial peptide, mitochondria, caspase, blebbing, shrinkage, nuclear fragmentation, chromatin condensation, apoptopodia, ROS, acidification, fission, fusion
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Feature Application: Characterizing cell metabolism
This Feature Application highlights the huge potential of Nanolive cell imaging for metabolic studies. We begin by proving that mitochondria and LDs have specific RI signals that allow them to be identified and mapped, in 3D (case study 1). We show that it is possible to image fission-fusion dynamics in mitochondria (case study 2), induce and detect mitochondrial dysfunction (case study 3) and then restore mitochondrial function by the addition of a specific drug (case study 4). Finally, we show that it is possible to quantify LD dynamics in unperturbed (case study 5) and drug-perturbed conditions (case study 6).
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Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes
Authors: Paria Ali Pour, M. Cristina Kenney and Arash Kheradvar
DOI: https://doi.org/10.1161/JAHA.119.014501, 2020
Published in: Journal of the American Heart Association
Tags: Mitochondria and cell metabolism, mitochondrial transplantation, cardiac patients, cardiology, ATP, non-autologous, acute stress