Drug Discovery with label-free imaging

Perform parallel and automated label-free drug perturbation assays on live cells and over long periods of time
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Drug efficacy testing

Selexipag (Uptravi®) is a marketed drug for the treatment of pulmonary arterial hypertension (PAH), released by Actelion Pharmaceuticals Ltd.

The 3D Cell Explorer was used to successfully monitor drug induced cell shape changes in real-time.

Read our detailed blogpost here.

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Mechanism of drug action

Khondrion’s drug KH176 rescues the cytotoxic effect by Buthionine sulfoximine (BSO).

Read our detailed blogpost here.

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Mechanism of drug action

Khondrion’s drug KH176 rescues the cytotoxic effect by Buthionine sulfoximine (BSO).

Read our detailed blogpost here.

Request a quote or demo >

 

Targeted cancer therapy

This video shows mouse breast cancer cells that were treated with the control Antibody Drug Conjugate (ADC ) which divided undisturbed for almost 60 hours (left). Treated cells were dead 34h 30 after treatment with the tumor-selective ADC (right).

The 3D Cell Explorer was used for long-time live cell imaging of the cell samples (up to approximately 60 hours of continuous imaging).

Read our detailed blogpost here.

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Drug screening

This video demonstrates a time-lapse of a comparative study of multiple drug perturbations performed in a multi-well setup featuring pre-adipocytes perturbed by various drugs.
We applied the following treatments on pre-adipocyte cells: Tamoxifen, Raptinal and Shikonin at various concentrations, with or without mitoTracker and observed the effects of such drugs over 26 hours compared to the relevant control conditions.

Download our application note here.

Request a quote or demo >

 

Drug screening

This video demonstrates a time-lapse of a comparative study of multiple drug perturbations performed in a multi-well setup featuring pre-adipocytes perturbed by various drugs.
We applied the following treatments on pre-adipocyte cells: Tamoxifen, Raptinal and Shikonin at various concentrations, with or without mitoTracker and observed the effects of such drugs over 26 hours compared to the relevant control conditions.

Download our application note here.

 Request a quote or demo >

Application Note

Application Note: Investigating multiple drug-induced perturbations

 

In this application note we will discuss the new research possibilities offered by the CX-A for the study of drug-induced perturbations.

Download our Feature Application Note >

Webinar

Watch our Webinar: Automated Label-free Live Cell Imaging with the CX-A

 

Dr. Mathieu Frechin, Head of Quantitative Biology at Nanolive will introduce you the CX-A and its functionalities. He will outline the possibilities for parallelized experiments and image production capabilities.

In particular, the following topics will be covered:

  • Nanolive’s imaging technology
  • Presentation of the new hardware and software
  • Acquisition highlights showing data quality and new possibilities for label-free drug screening

Sign up to watch the webinar:

Webinar

Watch our Webinar: Accelerating oncology drug discovery with label-free imaging

 

In this webinar, Dr. Emma Gibbin, Communications Specialist at Nanolive will discuss the advantages of using label-free live cell imaging in the drug discovery process and show how Nanolive’s automated live cell imaging solution the CX-A, can be used to:

  • observe unique drug-induced phenotypes that fluorescence microscopy cannot capture
  • record dynamic cellular responses to drug perturbations
  • automate in vitro screening studies.

Dr. Gibbin will present novel results from two experimental screens designed to test the phenotypic and morphological responses of pre-adipocyte and cancer cells to 8 inhibitors or modulators of kinase activity.

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Video Library

Restored phagocytosis of cancer cells
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Compare Nanolive's microscopes

3D CELL EXPLORER

Budget-friendly, easy-to-use, compact solution for high quality non-invasive 4D live cell imaging             

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3D CELL EXPLORER-fluo

Multimodal Complete Solution: combine high quality non-invasive 4D live cell imaging with fluorescence

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CX-A

Automated live cell imaging: a unique walk-away solution for long-term live cell imaging of single cells and cell populations

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