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  • A protocol for revealing oral neutrophil heterogeneity by single-cell immune profiling in human saliva

    Authors: Saibyasachi N. Choudhury, Mark Novotny, Brian D. Aevermann, Steven Lee, Aishwarya Mandava, Yu Qian, Richard H. Scheuermann, Marcelo Freire

    10.21203/rs.3.pex-953/v1, 2020

    Published in: Research Square

    Tags: single-cell, transcriptomics, saliva, neutrophils, heterogeneity

  • Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

    Authors: Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl , Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch

    DOI: https://doi.org/10.3390/ijms21134808, 2020 

    Published in: International Journal of Molecular Sciences

    Tags: myeloid cells; primitive macrophages; induced pluripotent stem cells; in vitro characterization; drug discovery; disease modeling

  • Netome: The Molecular Characterization of Neutrophil Extracellular Traps (NETs)

    Authors: David Scieszka, Yi-Han Lin, Weizhong Li, Saibyasachi Choudhury, Yanbao Yu, Marcelo Freire

    DOI: https://doi.org/10.21873/anticanres.14232, 2020

    Published in: bioRxiv

    Tags: Immunology, single cell characterization, Immunology, single cell characterization, CX, HL60, HL-60, ATCC, NETs, neutrophils, extracellular DNA, genomics, proteomics, NETOME, inflammation, infection, antimicrobial

  • Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus

    Authors: Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel and Martin F. Bachmann

    DOI: https://doi.org/10.3390/vaccines8010116, 2020

    Published in: Vaccines

    Tags: Immunology, type 2 diabetes mellitus, T2DM, diabetes, insulin, amyloid deposits, islet amyloid polypeptide (IAPP), pancreas, pancreatic islets, virus-like particles, VLPs, hyperglycemia, cytokine, IL-1b

  • Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes

    Authors: Svadlakova, T.; Hubatka, F.; Turanek Knotigova, P.; Kulich, P.; Masek, J.; Kotoucek, J.; Macak, J.; Motola, M.; Kalbac, M.; Kolackova, M.; Vankova, R.; Vicherkova, P.; Malkova, A.; Simeckova, P.; Volkov, Y.; Prina-Mello, A.; Kratochvilova, I.; Fiala, Z.; Raska, M.; Krejsek, J.; Turanek, J

    DOI: https://doi.org/10.3390/nano10030418, 2020

    Published in: nanomaterials

    Tags: Immunology, graphene platelets, carbon nanotubes, inflammasome NLRP3, cathepsin B, macrophages, THP-1, bioresistance, proinflammatory, inflammation, canonical pathway, alternative pathway, MWCNT, PAMPs

  • A Gain-Of-Function RAC2 Mutation Is Associated With Bone-Marrow Hypoplasia And An Autosomal Dominant Form Of Severe Combined Immunodeficiency

    Authors: Chantal Lagresle-Peyrou, Aurélien Olichon, Hanem Sadek, Philippe Roche, Claudine Tardy, Cindy Da Silva, Alexandrine Garrigue, Alain Fischer, Despina Moshous, Yves Collette, Capucine Picard, Jean Laurent Casanova, Isabelle André, Marina Cavazzana

    DOI: https://doi.org/10.3324/haematol.2019.230250, 2020

    Published in: Haematologica

    Tags: Immunology, severe combined immunodeficiencies, SCIDs, T cells, B cells, leukopenia, RAC2 gene, p.G12R, hematopoietic stem cell transplantation, stem cell, gain of function

  • E-Cigarette Use Increases Susceptibility to Bacterial Infection by Impairment of Human Neutrophil Chemotaxis, Phagocytosis and NET Formation

    Authors: Ross Corriden, Alexander Moshensky, Christine M Bojanowski, Angela Meier, Jason Chien, Ryan K Nelson, Laura E. Crotty Alexander

    DOI: https://doi.org/10.1152/ajpcell.00045.2019, 2019

    Published in: American Journal of Physiology

    Tags: Immunology, single cell characterization, chemotaxis, E-cigarette, human neutrophils, neutrophil extracellular trap, Pseudomonas; reactive oxygen species, sepsis

     

  • Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction

    Authors: Gabriela Pinget, Jian Tan, Bartlomiej Janac, Nadeem O. Kaakoush, Alexandra Sophie Angelatos, John O’Sullivan6, Yen Chin Koay, Frederic Sierro, Joel Davis, Shiva Kamini Divakarla, Dipesh Khanal, Robert J. Moore, Dragana Stanley, Wojciech Chrzanowski and Laurence Macia

    DOI: https://doi.org/10.3389/fnut.2019.00057, 2019

    Published in: frontiers in Nutrition

    Tags: Microbiology and biofilms, host-pathogen interactions, Immunology