Scientific Publications

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  • Effects of Glycyrrhizin on Multi-Drug Resistant Pseudomonas aeruginosa

    Authors: Nicholas J. Carruthers, Sharon A. McClellan, Mallika Somayajulu, Ahalya Pitchaikannu, Denise Bessert, Xudong Peng, Kylie Huitsing, Paul M. Stemmer and Linda D. Hazlett

    https://doi.org/10.3390/pathogens9090766, 2020

    Published in: Pathogens

    Tags: Pseudomonas aeruginosa; glycyrrhizin; multi-drug resistance; proteomics

  • Protein corona determines the cytotoxicity of nanodiamonds implications of corona formation and its remodelling on nanodiamond applications in biomedical imaging and drug delivery

    Authors: Dipesh Khanal, Qingyu Lei, Gabriela Pinget, Daniel A. Cheong, Archana Gautam, Ridhwan Yusoff, Bowyn Su, Seiji Yamaguchi, Alexey Kondyurin, Jonathan C. Knowles, George Georgiou, Laurence Macia, Jun-Hyeog Jang, Iqbal Ramzan, Kee Woei Ng, Wojciech Chrzanowski

    DOI: https://doi.org/10.1039/D0NA00231C, 2020 

    Published in: Nanoscale Advances

    Tags: nanodiamonds; drug delivery; protein corona; nanoparticles; macrophages

  • Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

    Authors: Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl , Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch

    DOI: https://doi.org/10.3390/ijms21134808, 2020 

    Published in: International Journal of Molecular Sciences

    Tags: myeloid cells; primitive macrophages; induced pluripotent stem cells; in vitro characterization; drug discovery; disease modeling

  • Feature Application: Drug Discovery

    Authors: Nanolive SA, 2020

    Tags: Drug discovery, CX-A, automated label-free live cell imaging, drug screening, target identification, mechanism of action studies, multi-well

  • BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

    Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

    DOI: https://doi.org/10.1117/1.JBO.24.4.046503, 2019

    Published in: Journal of Biomedical Optics

    Tags: Single cell characterization, drug discovery, neuroscience, rat, C6 glial cells, methamphetamine, Raman spectroscopy, apoptosis

  • Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells

    Authors: Diana Díaz-García, Lucia Sommerova, Andrea Martisova, Hana Skoupilova, Sanjiv Prashar, Tomas Vaculovic, Viktor Kanicky, Isabel del Hierro, Roman Hrstka, Santiago Gómez-Ruiz

    DOI: https://doi.org/10.1016/j.micromeso.2020.110154, 2020

    Published in: Microporous and Mesoporous Materials

    Tags: Drug discovery, immunooncology & oncology, 

  • Stimuli-sensitive fatty acid-based microparticles for the treatment of lung cancer

    Authors: Katarzyna Reczyńska, Patrycja Marchwica, Dipesh Khanal, Tomasz Borowik, Marek Langner, Elżbieta Pamuła, Wojciech Chrzanowski

    DOI: https://doi.org/10.1016/j.msec.2020.110801, 2020

    Published in: Materials and Science Engineering: C

    Tags: Immunooncology & oncology, single cell characterization, drug discovery, lung cancer, cancer therapy, superparamagnetic iron oxide nanoparticles, SPION, solid lipid microparticles, lipid, stimuli-sensitive drug carriers, anticancer drug, paclitaxel, lauric acid, LAU, myrisctic acid, palmitic acid, MYR, PAL, cell viability

  • Enhancement of the biological autoluminescence by mito-liposomal gold nanoparticle nanocarriers

    Authors: Hadi Sardarabadi, Djamel Eddine Chafai, Fatemeh Gheybi, Pezhman Sasanpour, Hashem Rafii-Tabar, Michal Cifra

    DOI: https://doi.org/10.1016/j.jphotobiol.2020.111812, 2020

    Published in: Journal of Photochemistry and Photobiology B: Biology

    Tags: Mitochondria and cell metabolism, drug discovery, immunooncology & oncology, nanocarrier, mitochondria, biological autoluminescence, BAL, ROS, reactive oxygen species, liposome, gold nanoparticle

  • Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

    Authors: Wen-Yueh Hung, Jer-Hwa Chang, Yu Cheng, Guo-Zhou Cheng, Hsiang-Ching Huang, Michael Hsiao, Chi-Li Chung, Wei-Jiunn Lee and Ming-Hsien Chien

    DOI: https://doi.org/10.1038/s41419-019-1785-9, 2019

    Published in: Cell Death & Disease

    Tags: Drug discovery, immunooncology & oncology, mitochondria and cell metabolism, anticancer, chemotherapy, apoptosis, autophagy, drug discovery, penfluridol, lung cancer, antitumor, non-small-cell lung cancer, NSCLC, orthotopic xenograft model, viability, motility, p38

  • Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

    Authors: T. B. Steinbichler, D. Savic, D. Dejaco, A. Romani, B. Kofler, I. I. Skvortsova, H. Riechelmann, J. Dudas

    DOI: https://doi.org/10.1007/s12307-019-00228-y, 2019

    Published in: Cancer Microenvironment

    Tags: Drug discovery, immunooncology & oncology, mitochondria and cell metabolism, epithelial mesenchymal crosstalk, EMC, tumor, tumor stroma, associated fibroblasts, cancer, head and neck cancer, chemotherapy, IL-6, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium