Scientific Publications

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  • Effects of Glycyrrhizin on Multi-Drug Resistant Pseudomonas aeruginosa

    Authors: Nicholas J. Carruthers, Sharon A. McClellan, Mallika Somayajulu, Ahalya Pitchaikannu, Denise Bessert, Xudong Peng, Kylie Huitsing, Paul M. Stemmer and Linda D. Hazlett

    https://doi.org/10.3390/pathogens9090766, 2020

    Published in: Pathogens

    Tags: Pseudomonas aeruginosa; glycyrrhizin; multi-drug resistance; proteomics

  • Protein corona determines the cytotoxicity of nanodiamonds implications of corona formation and its remodelling on nanodiamond applications in biomedical imaging and drug delivery

    Authors: Dipesh Khanal, Qingyu Lei, Gabriela Pinget, Daniel A. Cheong, Archana Gautam, Ridhwan Yusoff, Bowyn Su, Seiji Yamaguchi, Alexey Kondyurin, Jonathan C. Knowles, George Georgiou, Laurence Macia, Jun-Hyeog Jang, Iqbal Ramzan, Kee Woei Ng, Wojciech Chrzanowski

    DOI: https://doi.org/10.1039/D0NA00231C, 2020 

    Published in: Nanoscale Advances

    Tags: nanodiamonds; drug delivery; protein corona; nanoparticles; macrophages

  • Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

    Authors: Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl , Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch

    DOI: https://doi.org/10.3390/ijms21134808, 2020 

    Published in: International Journal of Molecular Sciences

    Tags: myeloid cells; primitive macrophages; induced pluripotent stem cells; in vitro characterization; drug discovery; disease modeling

  • BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

    Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

    DOI: https://doi.org/10.1117/1.JBO.24.4.046503, 2019

    Published in: Journal of Biomedical Optics

    Tags: Single cell characterization, drug discovery, neuroscience, rat, C6 glial cells, methamphetamine, Raman spectroscopy, apoptosis

  • Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells

    Authors: Diana Díaz-García, Lucia Sommerova, Andrea Martisova, Hana Skoupilova, Sanjiv Prashar, Tomas Vaculovic, Viktor Kanicky, Isabel del Hierro, Roman Hrstka, Santiago Gómez-Ruiz

    DOI: https://doi.org/10.1016/j.micromeso.2020.110154, 2020

    Published in: Microporous and Mesoporous Materials

    Tags: Drug discovery, immunooncology & oncology, 

  • Stimuli-sensitive fatty acid-based microparticles for the treatment of lung cancer

    Authors: Katarzyna Reczyńska, Patrycja Marchwica, Dipesh Khanal, Tomasz Borowik, Marek Langner, Elżbieta Pamuła, Wojciech Chrzanowski

    DOI: https://doi.org/10.1016/j.msec.2020.110801, 2020

    Published in: Materials and Science Engineering: C

    Tags: Immunooncology & oncology, single cell characterization, drug discovery, lung cancer, cancer therapy, superparamagnetic iron oxide nanoparticles, SPION, solid lipid microparticles, lipid, stimuli-sensitive drug carriers, anticancer drug, paclitaxel, lauric acid, LAU, myrisctic acid, palmitic acid, MYR, PAL, cell viability

  • Enhancement of the biological autoluminescence by mito-liposomal gold nanoparticle nanocarriers

    Authors: Hadi Sardarabadi, Djamel Eddine Chafai, Fatemeh Gheybi, Pezhman Sasanpour, Hashem Rafii-Tabar, Michal Cifra

    DOI: https://doi.org/10.1016/j.jphotobiol.2020.111812, 2020

    Published in: Journal of Photochemistry and Photobiology B: Biology

    Tags: Mitochondria and cell metabolism, drug discovery, immunooncology & oncology, nanocarrier, mitochondria, biological autoluminescence, BAL, ROS, reactive oxygen species, liposome, gold nanoparticle

  • Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

    Authors: Wen-Yueh Hung, Jer-Hwa Chang, Yu Cheng, Guo-Zhou Cheng, Hsiang-Ching Huang, Michael Hsiao, Chi-Li Chung, Wei-Jiunn Lee and Ming-Hsien Chien

    DOI: https://doi.org/10.1038/s41419-019-1785-9, 2019

    Published in: Cell Death & Disease

    Tags: Drug discovery, immunooncology & oncology, mitochondria and cell metabolism, anticancer, chemotherapy, apoptosis, autophagy, drug discovery, penfluridol, lung cancer, antitumor, non-small-cell lung cancer, NSCLC, orthotopic xenograft model, viability, motility, p38

  • Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

    Authors: T. B. Steinbichler, D. Savic, D. Dejaco, A. Romani, B. Kofler, I. I. Skvortsova, H. Riechelmann, J. Dudas

    DOI: https://doi.org/10.1007/s12307-019-00228-y, 2019

    Published in: Cancer Microenvironment

    Tags: Drug discovery, immunooncology & oncology, mitochondria and cell metabolism, epithelial mesenchymal crosstalk, EMC, tumor, tumor stroma, associated fibroblasts, cancer, head and neck cancer, chemotherapy, IL-6, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium

  • Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity

    Authors: Chao Sun, Xiongxiong Liu, Bing Wang, Zhenhua Wang, Yang Liu, Cuixia Di, Jing Si, Hongyan Li, Qingfeng Wu, Dan Xu, Ji Li, Gang Li, Yupei Wang, Fang Wang and Hong Zhang

    DOI: https://dx.doi.org/10.7150%2Fthno.33100, 2019

    Published in: Theranostics

    Tags: Drug discovery, Immunooncology & Oncology, Mitochondria and Cell Metabolism, cellular respiration, cancer, glycolysis, mitochondria, mitochondrial dysfunction, apoptosis, radiotheraphy, resistance, glioma, endoytosis, aerobic respiration, Warburg effect, radiosensitivity, astrocytes, NAD, NADH