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Scientific Publications

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  • Elevated CLOCK and BMAL1 contribute to the impairment of aerobic glycolysis from astrocytes in Alzheimer’s disease

    Authors: Ik Dong Yoo, Min Woo Park, Hyeon Woo Cha, Sunmi Yoon, Napissara Boonpraman, Sun Shin Yi, Jong-Seok Moon

    https://doi.org/10.3390/ijms21217862, 2020

    Published in: International Journal of Molecular Sciences

    Tags: CLOCK; BMAL1; aerobic glycolysis; astrocytes; Alzheimer’s disease

  • Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1

    Authors: John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rose M. De Guzman, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander Khmaladze, Alexey Semyanov, Damian G. Zuloaga, Michele Migliore, Annalisa Scimemi

    https://doi.org/10.1016/j.celrep.2020.108255, 2020

    Published in: Cell Reports

    Tags: circadian rhythmicity; NMDA receptors; corticosterone; cognitive processing; hippocampal neurons

  • BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

    Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

    DOI: https://doi.org/10.1117/1.JBO.24.4.046503, 2019

    Published in: Journal of Biomedical Optics

    Tags: Single cell characterization, drug discovery, neuroscience, rat, C6 glial cells, methamphetamine, Raman spectroscopy, apoptosis

  • TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment

    Authors: Ying-Fa Chen, Po-Chang Shih, Hsiao-Mei Kuo, San-Nan Yang, Yen-You Lin, Wu-Fu Chen, Shiow-Jyu Tzou, Hsin-Tzu Liu and Nan-Fu Chen

    DOI: https://doi.org/10.1002/cam4.3005, 2020

    Published in: Cancer Medicine

    Tags: Immunooncology and oncology, neuroscience, cell mobility, glioblastoma multiforme, infiltration, TP3, tumor microenvironment, adhesion, migration, invasion, invasiveness, filopodia, cell attachment, metastasis, kinase, paxillin, RAS, AKT, ERK, JNK, p38

  • Advancing methods for the analysis of glioblastoma cell motion using quantitative time lapse holographic imaging and cellular tomography

    Authors: Ed Luther, Livia Mendes, Nina Filiczak, Aditi Jhaveri, Lara Milane, Vladimir Torchilin

    DOI: https://doi.org/10.1117/12.2510236, 2019

    Published in: Society of Photo-Optical Instrumentation Engineers

    Tags: Neuroscience, Immunooncology & Oncology, mitochondria and cell metabolism, glioblastoma, motility, mitochondria, fission, fusion, nanotubes, spheroids

  • Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling

    Authors: Hyunsook Kang, Seong Jun Choi, Kye Hoon Park, Chi-Kyou Lee, and Jong-Seok Moon

    DOI: https://doi.org/DOI: 10.3390/ijms21020476, 2020

    Published in: International Journal of Molecular Sciences

    Tags: Neuroscience, single cell characterization, mitochondria and cell metabolism, glycolysis, EGFR signaling, apoptosis, alcohol, HEI-OC1 cells, glucose metabolism, glucose, auditory sytem, apoptosis, hexokinase 1, HK1, AKT phosphorylation

  • Caspase-8 deficiency induces a switch from TLR3-induced apoptosis to lysosomal cell death in neuroblastoma cell lines

    Authors: Marie-Anaïs Locquet, Gabriel Ichim, Aurelie Dutour, Serge Lebeque, Marie Castets, Kathrin Weber

    DOI: https://doi.org/10.1101/2020.01.13.904987, 2020

    Published in: BioRxiv

    Tags: Neuroscience, single cell characterization, immunooncology and oncology, TLR3, cancer, TLR3-induced cell death, apoptosis, lysosomes, lysosomal cell death, IFN-1, caspase-8, neuroblastoma, cathepsins

  • Beyond the suprachiasmatic nucleus: circadian rhythmicity shapes astrocyte morphology and neuronal function in hippocampal area CA1

    Authors: John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander Khmaladze, Alexey Semyanov, Michele Migliore and Annalisa Scimemi

    DOI: https://doi.org/10.1101/666073, 2019

    Published in: bioRxiv

    Tags: Neuroscience, single cell characterization, suprachiasmatic nucleus, SCN, hypothalamus, rhythmic activity, memory-dependent, hippocampus, CA1, circadian rhythmicity, synaptic transmission, pyramidal neurons, NMDA receptors, astrocytes

  • Methamphetamine-induced apoptosis in glial cells examined under markerfree imaging modalities

    Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

    DOI: https://doi.org/10.1117/1.JBO.24.4.046503, 2019

    Published in: Journal of Biomedical Optics

    Tags: Single cell characterization, Drug discovery, Neuroscience, rat, C6 glial cells, methamphetamine, Raman spectroscopy, apoptosis

  • Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells

    Authors: Sławomir Jaworski, Barbara Strojny, Ewa Sawosz, Mateusz Wierzbicki, Marta Grodzik, Marta Kutwin, Karolina Daniluk and André Chwalibog

    DOI: https://doi.org/10.3390/ijms20030650, 2019

    Published in: International Journal of Molecular Sciences

    Tags: Immunooncology and Oncology, Mitochondria and cell metabolism, Neuroscience, graphene, graphene-based nanomaterials, U87 glioma cells, HS-5 cells, chicken embryo chorioallantoic membrane, pristine, ROS, mitochondrial membrane potential, oxidative stress, apoptosis, necrosis