Oncology & Immuno oncology
Long term non-invasive live cell imaging of the interactions between immune and cancer cells with Nanolive Compare Nanolive's ProductsThe one and only high resolution long-term live cell imaging tool for investigating immune synapsis assembly and organization, non-invasively. Nanolive’s microscopes enable researchers to monitor the spatial and temporal dynamics of T cell activation and their interactions with cancer cells.
Antibodies being used as a T cell targeting system to wipe out cancer cells
Nanolive’s automated microscope, the CX-A, allows scientists to monitor dynamic interactions between immune cells and cancer cells at the population level, unperturbed, and with zero phototoxicity involved. Here, the CX-A was used to visualize whether the addition of bispecific antibodies enhanced the cancer-killing ability of cytotoxic T-Cells. Images were taken every four and a half minutes, for twenty hours. Read the blogpost here.
Inside the Immune System: T cells Killing Colon Cancer Cells
This video shows T cells attacking and killing cancer cells. The cancer cell line used here, is MC38-OVA, a transduced colon cancer cell line that expresses the ovalbumin (OVA) model antigen.
These cells were imaged with the 3D Cell Explorer.
T cell Attack & Cancer Evasion
This video was kindly provided by Joao Martins, Research Technician at the Champalimaud Centre for the Unknown, Portugal. Joao shared the original video imaged with the 3D Cell Explorer on LinkedIn and had a wide impact on scientists and researchers with hundreds of thousand views.
T cell Attack & Cancer Evasion
This video was kindly provided by Joao Martins, Research Technician at the Champalimaud Centre for the Unknown, Portugal. Joao shared the original video imaged with the 3D Cell Explorer on LinkedIn and had a wide impact on scientists and researchers with hundreds of thousand views.
Scientific Publications
Nanolive label-free live cell imaging has already shed light on many important topics in the field of immuno-oncology and oncology research. To get inspired and learn how your research can benefit from our technology, we invite you to check out these scientific articles published by our clients.
Feature Application
Feature application: Characterising cancer cells and their interactions with immune cells
One of the most promising avenues of research in immune oncology is long-term, live imaging. Capturing dynamic biological processes in real time holds the key to understanding which cell-cell interactions promote a successful immune response, and which promote disease.
Webinar
Watch our Webinar: Label-free live cell imaging meets Immuno oncology
Dr. Mathieu Frechin, Head of Quantitative Biology at Nanolive will introduce you to our holotomographic microscopy and its implications in the field of Immuno Oncology. During the webinar he will discuss the opportunities that are created by the usage of Nanolive’s label-free technology in the field of immune system research. In particular, the following topics will be covered:
- Immuno oncology in the spotlight – strategic importance of studying the immune system.
- Current state of the art of live cell imaging in the field of immunology – what Nanolive’s technology can bring to the field.
- New live cell research possibilities to understand the cell-cell interactions of the immune system (examples).
Please register here to view the webinar on-demand:
Webinar
Watch our Webinar: Accelerating oncology drug discovery with label-free imaging
In this webinar, Dr. Emma Gibbin, Communications Specialist at Nanolive will discuss the advantages of using label-free live cell imaging in the drug discovery process and show how Nanolive’s automated live cell imaging solution the CX-A, can be used to:
- observe unique drug-induced phenotypes that fluorescence microscopy cannot capture
- record dynamic cellular responses to drug perturbations
- automate in vitro screening studies.
Dr. Gibbin will present novel results from two experimental screens designed to test the phenotypic and morphological responses of pre-adipocyte and cancer cells to 8 inhibitors or modulators of kinase activity.
Please register here to view the webinar on-demand:
Video library
Activated T-Cell Killing Cancer Cell.
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Lung Cancer Apoptosis of A549 cells treated with BA6.
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T-cells killing cancer cells
Human peripheral blood mononuclear cells hunt melanoma cells in co-culture
Antibody Drug Conjugate (ADCs) killing mouse breast cancer cells.
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Restored phagocytosis of cancer cells
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Compare Nanolive's microscopes
3D CELL EXPLORER
Budget-friendly, easy-to-use, compact solution for high quality non-invasive 4D live cell imaging
3D CELL EXPLORER-fluo
Multimodal Complete Solution: combine high quality non-invasive 4D live cell imaging with fluorescence
CX-A
Automated live cell imaging: a unique walk-away solution for long-term live cell imaging of single cells and cell populations